Analysis of radiation therapy in a model of triple-negative breast cancer brain metastasis

Clinical & Experimental Metastasis
DeeDee SmartPatricia S Steeg

Abstract

Most cancer patients with brain metastases are treated with radiation therapy, yet this modality has not yet been meaningfully incorporated into preclinical experimental brain metastasis models. We applied two forms of whole brain radiation therapy (WBRT) to the brain-tropic 231-BR experimental brain metastasis model of triple-negative breast cancer. When compared to sham controls, WBRT as 3 Gy × 10 fractions (3 × 10) reduced the number of micrometastases and large metastases by 87.7 and 54.5 %, respectively (both p < 0.01); whereas a single radiation dose of 15 Gy × 1 (15 × 1) was less effective, reducing metastases by 58.4 % (p < 0.01) and 47.1 % (p = 0.41), respectively. Neuroinflammation in the adjacent brain parenchyma was due solely to a reaction from metastases, and not radiotherapy, while adult neurogenesis in brains was adversely affected following both radiation regimens. The nature of radiation resistance was investigated by ex vivo culture of tumor cells that survived initial WBRT ("Surviving" cultures). The Surviving cultures surprisingly demonstrated increased radiosensitivity ex vivo. In contrast, re-injection of Surviving cultures and re-treatment with a 3 × 10 WBRT regimen significantly reduced the number of la...Continue Reading

References

Aug 1, 1990·JAMA : the Journal of the American Medical Association·J N Yamazaki, W J Schull
Jun 1, 1989·Neurology·L M DeAngelisJ B Posner
Aug 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T YonedaR Nishimura
May 17, 2003·Science·Monica Garcia-BarrosRichard Kolesnick
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kevin CamphausenPhilip J Tofilon
Oct 11, 2005·Journal of Neuro-oncology·Igor T Gavrilovic, Jerome B Posner
Oct 10, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chris HeynPaula J Foster
Jan 25, 2007·Neurosurgery Clinics of North America·John R FikeCharles L Limoli
Feb 20, 2007·Cancer Research·Emily I ChenBrunhilde Felding-Habermann
Apr 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Amol GhiaMinesh P Mehta
Sep 6, 2007·Cell and Tissue Research·Marta Andres-MachJohn R Fike
Jul 24, 2008·Clinical & Experimental Metastasis·Daniel P FitzgeraldPatricia S Steeg
Sep 19, 2008·Radiation Oncology·Andrew BaschnagelKevin Camphausen
Oct 17, 2008·Developmental Disabilities Research Reviews·Michelle Monje
May 8, 2009·Nature·Paula D BosJoan Massagué
Aug 1, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Florian HeitzAndreas du Bois
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason S SnyderHeather A Cameron
Dec 22, 2009·Nature Medicine·Yvonne KienastFrank Winkler
Apr 13, 2010·The American Journal of Pathology·Mihaela Lorger, Brunhilde Felding-Habermann
Sep 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul R LockmanQuentin R Smith
Oct 26, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vinai GondiMinesh P Mehta
Nov 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brunilde GrilPatricia S Steeg
Apr 8, 2011·Nature Reviews. Cancer·Patricia S SteegQuentin R Smith
Jul 20, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adam M BrufskyDenise A Yardley
Oct 13, 2011·Journal of Visualized Experiments : JoVE·Debabrata SahaDawen Zhao
Jan 15, 2013·International Journal of Radiation Oncology, Biology, Physics·Vinai GondiWolfgang A Tomé
Mar 15, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Martina BoströmKlas Blomgren
Apr 12, 2013·Science Translational Medicine·Lixin ZhangDario Marchetti
Apr 16, 2013·The American Journal of Pathology·Brunilde GrilFernando Vidal-Vanaclocha
Sep 26, 2013·International Journal of Radiation Oncology, Biology, Physics·Yani ZouTing-Ting Huang
Oct 30, 2013·International Journal of Radiation Biology·Antiño R AllenJohn R Fike
Mar 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Diane PalmieriPatricia S Steeg

❮ Previous
Next ❯

Citations

Mar 2, 2018·NMR in Biomedicine·Amanda M HamiltonPaula J Foster
Dec 1, 2018·International Journal of Radiation Biology·William CroweDawen Zhao
Mar 6, 2019·Radiation Research·Phuongmai NguyenDeeDee K Smart
Jul 10, 2020·Cancer Research·Manuel ValienteFrank Winkler
Dec 16, 2020·Advanced Drug Delivery Reviews·M Masmudi-MartínM Valiente

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
P E PostmusG Giaccone
Clinical Oncology : a Journal of the Royal College of Radiologists
B SaitK Altundag
International Journal of Radiation Oncology, Biology, Physics
Ashraf S Mahmoud-AhmedGene H Barnett
Clinical Oncology : a Journal of the Royal College of Radiologists
R VenkitaramanS Upadhyay
© 2021 Meta ULC. All rights reserved