PMID: 16615652Apr 18, 2006Paper

Analysis of repeated pregnancy outcomes

Statistical Methods in Medical Research
Germaine Buck LouisPregnancy Modeling Working Group

Abstract

Women tend to repeat reproductive outcomes, with past history of an adverse outcome being associated with an approximate two-fold increase in subsequent risk. These observations support the need for statistical designs and analyses that address this clustering. Failure to do so may mask effects, result in inaccurate variance estimators, produce biased or inefficient estimates of exposure effects. We review and evaluate basic analytic approaches for analysing reproductive outcomes, including ignoring reproductive history, treating it as a covariate or avoiding the clustering problem by analysing only one pregnancy per woman, and contrast these to more modern approaches such as generalized estimating equations with robust standard errors and mixed models with various correlation structures. We illustrate the issues by analysing a sample from the Collaborative Perinatal Project dataset, demonstrating how the statistical model impacts summary statistics and inferences when assessing etiologic determinants of birth weight.

References

Jan 1, 1989·Journal of Clinical Epidemiology·M J KhouryR M Joesoef
Dec 1, 1988·International Journal of Epidemiology·R SkjaervenD Russell
Sep 1, 1985·British Journal of Obstetrics and Gynaecology·R A Carr-Hill, M H Hall
Jan 1, 1983·Acta Obstetricia Et Gynecologica Scandinavica·L S Bakketeig, H J Hoffman
Mar 1, 1982·American Journal of Public Health·A A LevinK J Ryan
Jul 7, 1994·The New England Journal of Medicine·R T LieR Skjaerven
Jan 1, 1997·Paediatric and Perinatal Epidemiology·B A Mueller, S M Schwartz
Jan 1, 1997·Paediatric and Perinatal Epidemiology·J M BakewellW F Schramm
Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Jan 16, 2002·American Journal of Epidemiology·Miguel A HernánAllen A Mitchell
Feb 20, 2004·The New England Journal of Medicine·Pamela J SurkanSven Cnattingius
Mar 1, 1951·Annals of Eugenics·M N KARNL S PENROSE

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Citations

Oct 26, 2006·Paediatric and Perinatal Epidemiology·Sherry G Selevan, Joseph B Stanford
Jun 25, 2008·Biometrics·Benjamin French, Patrick J Heagerty
Feb 4, 2009·Tropical Medicine & International Health : TM & IH·Natasha L LarkeNicolas Nagot
May 27, 2010·Obstetrics and Gynecology·Sohinee BhattacharyaSiladitya Bhattacharya
Dec 20, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Margaret H Bublitz, Laura R Stroud
Sep 21, 2012·Epidemiology·Germaine M Buck LouisKurunthachalam Kannan
Aug 9, 2011·Paediatric and Perinatal Epidemiology·Alexander C McLainGermaine M Buck Louis
Jun 27, 2008·Paediatric and Perinatal Epidemiology·Jennifer A Hutcheon, Robert W Platt
Oct 10, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·F C DenisonG Scotland
May 31, 2016·Journal of the Royal Statistical Society. Series C, Applied Statistics·Joanna H ShihKatherine L Grantz
Nov 20, 2013·BMC Pregnancy and Childbirth·Lee K TaylorJonathan Morris
Dec 9, 2016·Maternal & Child Nutrition·Jacob H GrundtTrond Markestad
Oct 16, 2015·American Journal of Public Health·Susitha WanigaratneMarcelo L Urquia
Oct 13, 2018·Paediatric and Perinatal Epidemiology·Jennifer A HutcheonKatherine A Ahrens
Mar 11, 2010·Current Opinion in Pediatrics·Donald R Mattison
Jul 2, 2020·American Journal of Epidemiology·Glen McGeeSebastien Haneuse
Jan 15, 2014·American Journal of Obstetrics and Gynecology·Gemma C SharpJane E Norman
Jul 29, 2010·Fertility and Sterility·Brian W WhitcombEric D Levens
Mar 27, 2021·Epidemiology·Sonia M GrandiRobert W Platt
Jun 9, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Xuerong WenKimford J Meador
Aug 21, 2021·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Erin HetheringtonAmy Metcalfe
Sep 19, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·L V LadforsO Stephansson
Feb 15, 2008·Pediatrics·Germaine M Buck LouisSusan Y Euling

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