Analysis of reproducibility and sensitivity of atraumatic measurements of regional cerebral blood flow in cerebrovascular diseases

Stroke; a Journal of Cerebral Circulation
P MericH Mamo

Abstract

We tested the reproducibility of consecutive measurements of regional cerebral blood flow (rCBF) made in 13 areas of each hemisphere in patients with cerebrovascular diseases by the atraumatic 133Xe intravenous injection method. The data were analysed by a two-compartment model similar to that used in the Obrist inhalation method. Four parameters derived from the model were tested: Fg (flow of the fast-clearing compartment), FF and W (respectively fractional flow and relative tissue weight of the same compartment), ISI (initial slope index as defined by Risberg et al.). No significant variation was found in these four parameters between two consecutive rest measurements for all the areas studied and whatever the time interval between the measurements. The variances of the differences of Fg and ISI between the two measurements were found to be similar to those found in normal healthy subjects. The variances of FF and, consequently, W were greater than the values determined in healthy volunteers. An attempt to improve the quality of the results, by correcting them for the effects of PaCO2 changes between the measurements, resulted on the contrary in a general increase of the variances of the differences, showing the inadequacy of...Continue Reading

References

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Feb 1, 1996·Italian Journal of Neurological Sciences·P MazzoneG Rosadini
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Mar 1, 1989·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·V de la SayetteB Lechevalier

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