Abstract
Anti-PD1/PD-L1 monoclonal antibodies (mAbs) increase overall survival compared to standard of care (SOC) in different tumors. However, a proportion of patients (pts) will have progressive disease (PD) as best response. We conducted a meta-analysis to study the rates of response comparing these antibodies with SOC. A search of published trials in MEDLINE and EMBASE analyzing anti-PD1/PD-L1mAbs monotherapy compared to SOC. Relative risk (RR) with 95% confidence interval (CI) of response rates between groups was estimated. Subgroup analyses for location of primary tumor, number of previous treatment lines, selected population by PD-L1 expression and type of radiological assessment were made. Twelve studies accounting for 6,700 pts were included (anti-PD1/PD-L1 mAbs: 3,451 pts; SOC: 3,249 pts [2,823 pts: chemotherapy, 426 pts: targeted therapy]). Adjusted response rates were (N, %): Complete Response (CR) (69/3153, 2.19%), Partial Response (PR) (596/3153, 18.90%), Stable Disease (SD) (632/2463, 25.66%) and PD (1027/2463, 41.70%); and CR (16/2955, 0.54%), PR (263/2955, 8.90%), SD (835/2269, 36.80%) and PD (834/2269, 36.76%) with anti-PD1/PD-L1 mAbs and SOC, respectively. Anti-PD1/PD-L1 mAbs improved CR rate (RR 3.48) and PR rate (RR...Continue Reading
References
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1981·Cancer·A B MillerA Winkler
Feb 3, 2000·Journal of the National Cancer Institute·P TherasseS G Gwyther
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 4, 2008·JAMA : the Journal of the American Medical Association·Charles L BennettMichael Henke
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jedd D WolchokF Stephen Hodi
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antoni RibasJohn A Glaspy
Jun 8, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mizuki NishinoF Stephen Hodi
Jul 31, 2013·Immunity·Daniel S Chen, Ira Mellman
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Feb 13, 2015·Medicine·Yaxiong ZhangWenhua Liang
Mar 22, 2015·The Lancet Oncology·Jeffrey S WeberJames Larkin
Jun 2, 2015·The New England Journal of Medicine·James LarkinJedd D Wolchok
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Jun 28, 2015·The Lancet Oncology·Antoni RibasAdil Daud
Aug 12, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Victoria L Chiou, Mauricio Burotto
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Dec 30, 2015·Lancet·Roy S HerbstEdward B Garon
Feb 10, 2016·The Lancet Oncology·Scott AntoniaNaiyer A Rizvi
Mar 10, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Stephen HodiJedd D Wolchok
Mar 12, 2016·Cell·A Karolina Palucka, Lisa M Coussens
Mar 14, 2016·Lancet·Louis FehrenbacherUNKNOWN POPLAR Study Group
Apr 24, 2016·Cancer Discovery·Rajarsi Mandal, Timothy A Chan
Aug 31, 2016·OncoTargets and Therapy·Xin WangJinming Yu
Sep 7, 2016·The Lancet Oncology·Howard L KaufmanPaul Nghiem
Oct 11, 2016·The New England Journal of Medicine·Robert L FerrisMaura L Gillison
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Nov 3, 2016·The New England Journal of Medicine·Vassiliki A Boussiotis
Nov 9, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stéphane ChampiatCharles Ferté
Dec 17, 2016·Lancet·Achim RittmeyerUNKNOWN OAK Study Group
Feb 18, 2017·The New England Journal of Medicine·Joaquim BellmuntUNKNOWN KEYNOTE-045 Investigators
Mar 9, 2017·The Lancet Oncology·Lesley SeymourUNKNOWN RECIST working group
Citations
Jan 18, 2020·Cells·Jessica MichieJane Oliaro
May 14, 2019·Oncotarget·Dinoop Ravindran Menon, Mayumi Fujita
Nov 13, 2019·Archives of Pathology & Laboratory Medicine·Eric E WalkUNKNOWN College of American Pathologists Personalized Health Care Committee
May 6, 2019·International Journal of Molecular Sciences·Rodolfo Chicas-SettPedro C Lara
Jul 25, 2019·The Cancer Journal·Marina Baretti, Nilofer Saba Azad
Jun 24, 2020·Hepatology International·Quan RaoZhongTao Zhang
Dec 20, 2018·Immunotherapy·Ahmad TarhiniMichael Atkins
Jan 5, 2020·Immunologic Research·Ming-Zhen ZhaoLi-Xin Sun
Sep 10, 2019·Molecular Systems Design & Engineering·Jonathan OzikPaul Macklin
Sep 30, 2020·Cancer Immunology, Immunotherapy : CII·Kyriakos P PapadopoulosJudy S Wang
Oct 3, 2020·Biomolecules·Jessica BridouxCatarina Xavier
Dec 2, 2020·International Journal of Molecular Sciences·Kevinn Eddy, Suzie Chen
Sep 6, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine D GrayIrene M Min
Mar 11, 2020·Acta Pharmacologica Sinica·Qian WuJi Cao
Nov 19, 2020·Cancer Research·Gregory M CresswellPhilip S Low
Jan 20, 2021·CPT: Pharmacometrics & Systems Pharmacology·Ignacio González-GarcíaHelen Moore
Nov 19, 2020·Journal for Immunotherapy of Cancer·Hannan GaoFan Wang
Dec 19, 2020·Cell Death and Differentiation·Tak W Mak
Feb 23, 2021·Frontiers in Oncology·Kevinn EddySuzie Chen
Mar 3, 2021·Cancer Treatment Reviews·Paolo TarantinoGiuseppe Curigliano
Mar 9, 2021·Oncoimmunology·Alberto Carretero-GonzálezGuillermo de Velasco
Jun 1, 2020·International Immunopharmacology·Liqin YaoWenxue Ma
Apr 26, 2021·Pharmacology & Therapeutics·Mohammad Kaisarul Islam, Johnson Stanslas
May 16, 2021·Acta Pharmacologica Sinica·Chang-Ling GuHao-Min Huang
Jun 5, 2021·Communications Biology·Marianne StrazzaAdam Mor
Jul 25, 2021·Cancers·Walid ShalataNir Peled
Jul 4, 2021·Nature Communications·Sara ValpioneRichard Marais
Aug 25, 2021·Bioorganic Chemistry·Gaochao LvJianguo Lin
Sep 8, 2020·Journal of the American Chemical Society·Moustafa T Gabr, Sanjiv S Gambhir
Oct 9, 2021·Journal for Immunotherapy of Cancer·Elisa BaldelliMariaelena Pierobon
Nov 5, 2021·Frontiers in Oncology·Shuai HeYahong Luo