Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques.

Virology
Jennifer L UmbachBryan R Cullen

Abstract

Rhesus rhadinovirus (RRV), a primate gamma-herpesvirus related to human Kaposi's sarcoma-associated herpesvirus (KSHV), causes a similar pattern of pathogenesis. Previously, RRV was shown to express 7 pre-microRNAs (pre-miRNAs) in latently infected cells. Using deep sequencing, we analyzed the pattern of small RNA expression in vivo using latently RRV-infected B-cell lymphoma and retroperitoneal fibromatosis tissues. We identified 15 virally encoded pre-miRNAs in both tumors, including all previously reported RRV pre-miRNAs. Although all 15 RRV pre-miRNAs, like all 12 KSHV pre-miRNAs, are located 3' to the conserved viral ORF71 gene and in the same transcriptional orientation, only one RRV miRNA is homologous to a KSHV miRNA. One previously identified RRV miRNA, miR-rR1-3, is actually a miRNA offset RNA (moRNA) derived from sequences located adjacent to pre-miR-rR1-3. Several other RRV-derived moRNAs were obtained, including one recovered >600 times. Together, this research provides a comprehensive list of the miRNAs and moRNAs encoded by RRV.

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 29, 2002·The EMBO Journal·Yoontae LeeV Narry Kim
Sep 17, 2002·Cell·Javier MartinezThomas Tuschl
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Dec 19, 2003·Genes & Development·Rui YiBryan R Cullen
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Mar 23, 2005·Nature Methods·Sébastien PfefferThomas Tuschl
Jun 4, 2005·The Journal of Biological Chemistry·Yan Zeng, Bryan R Cullen
Apr 9, 2008·Nature Biotechnology·Marc R FriedländerNikolaus Rajewsky
Jan 20, 2009·Nature Structural & Molecular Biology·Weiyang ShiBenjamin Haley
May 20, 2009·Genes & Development·Jennifer L Umbach, Bryan R Cullen
Feb 26, 2010·Journal of Virology·Igor JurakDonald M Coen

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Citations

Apr 22, 2014·Journal of Biotechnology·Grégoire StikDenis Rasschaert
Nov 3, 2014·Annual Review of Virology·Jennifer E Cox, Christopher S Sullivan
Sep 8, 2011·Genes & Development·Bryan R Cullen
Jan 10, 2012·Blood·Stefania BortoluzziUNKNOWN AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators
Jan 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jennifer E CoxChristopher S Sullivan
Jun 12, 2013·Current Opinion in Virology·Ryan D Estep, Scott W Wong
Jun 28, 2011·Trends in Molecular Medicine·Stefania BortoluzziAndrea Bisognin
Sep 20, 2011·Current Opinion in Virology·Bryan R Cullen
Jun 21, 2013·Oral Diseases·P PerezI Alevizos
Apr 12, 2012·The Journal of General Virology·Yongxiu YaoVenugopal Nair
Nov 22, 2011·Cell Host & Microbe·Eva GottweinBryan R Cullen
Jun 9, 2016·PloS One·Jin ZhaoRichard H Karas
Mar 2, 2018·Genes·Alexandra Iulia IrimieIoana Berindan-Neagoe
Aug 12, 2016·Journal of Virology·Rebecca L SkalskyScott W Wong
Nov 22, 2013·Journal of Virology·Rebecca L SkalskyBryan R Cullen
Jan 19, 2019·Non-coding RNA·Irena Misiewicz-KrzeminskaNorma C Gutiérrez
Nov 3, 2011·Future Virology·Masfique MehediHideki Ebihara
Mar 8, 2020·International Journal of Molecular Sciences·Enrico GaffoStefania Bortoluzzi
Mar 4, 2021·PLoS Pathogens·Anna K GroßkopfAlexander S Hahn

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