Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals

Journal of Vascular Surgery
K Craig KentGiampaolo Greco

Abstract

Abdominal aortic aneurysm (AAA) disease is an insidious condition with an 85% chance of death after rupture. Ultrasound screening can reduce mortality, but its use is advocated only for a limited subset of the population at risk. We used data from a retrospective cohort of 3.1 million patients who completed a medical and lifestyle questionnaire and were evaluated by ultrasound imaging for the presence of AAA by Life Line Screening in 2003 to 2008. Risk factors associated with AAA were identified using multivariable logistic regression analysis. We observed a positive association with increasing years of smoking and cigarettes smoked and a negative association with smoking cessation. Excess weight was associated with increased risk, whereas exercise and consumption of nuts, vegetables, and fruits were associated with reduced risk. Blacks, Hispanics, and Asians had lower risk of AAA than whites and Native Americans. Well-known risk factors were reaffirmed, including male gender, age, family history, and cardiovascular disease. A predictive scoring system was created that identifies aneurysms more efficiently than current criteria and includes women, nonsmokers, and individuals aged <65 years. Using this model on national statisti...Continue Reading

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References

Nov 1, 1995·Journal of Clinical Epidemiology·R F Gillum
Dec 26, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtE W Henneberg
Jun 24, 2004·Circulation·Anthony R BradyUNKNOWN UK Small Aneurysm Trial Participants
Nov 17, 2004·BMJ : British Medical Journal·Paul E NormanJames A Dickinson
Mar 1, 2005·Lancet·Tjun TangMichael Gaunt
May 28, 2005·Vascular and Endovascular Surgery·Christopher Longo, Gilbert R Upchurch
Oct 24, 2007·Journal of Vascular Surgery·Ageliki G Vouyouka, K Craig Kent
Sep 6, 2008·Journal of Vascular Surgery·Leila MureebeJames F McKinsey
Oct 8, 2009·JAMA : the Journal of the American Medical Association·Marc Schermerhorn

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Citations

Sep 4, 2012·Circulation. Cardiovascular Genetics·Tyler DuellmanJay Yang
Jun 6, 2013·TheScientificWorldJournal·Aneesh K RamaswamyCraig J Goergen
Sep 25, 2015·Expert Review of Cardiovascular Therapy·Grace H MinerMichael L Marin
Aug 27, 2015·Expert Review of Cardiovascular Therapy·Helena KuivaniemiGerard Tromp
Dec 3, 2015·Scandinavian Cardiovascular Journal : SCJ·M PerssonA Gottsäter
Jan 29, 2016·Atherosclerosis·Zi YeIftikhar J Kullo
Feb 11, 2014·Journal of Vascular Surgery·Robert J HyeMichael H Kanter
Nov 12, 2013·International Journal of Cardiology·Jerson Munoz-MendozaKathy Hebert
Jan 29, 2016·Journal of Vascular Surgery·John P DavisGilbert R Upchurch
Sep 10, 2013·Annals of Vascular Surgery·Ángel BarbaMaite Izagirre
Jul 28, 2013·The Surgical Clinics of North America·Toshio Takayama, Dai Yamanouchi
Sep 3, 2013·Progress in Cardiovascular Diseases·Martin Björck, Anders Wanhainen
Oct 16, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D T BradleyA E Hughes
Feb 24, 2016·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Darren G HaskettJonathan P Vande Geest
Jul 17, 2012·Annals of Vascular Surgery·Helena Kuivaniemi, James R Elmore
Dec 24, 2011·Journal of the American College of Surgeons·Rubie Sue JacksonRobyn A Macsata
Mar 10, 2016·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M ZarroukA Gottsäter
May 11, 2015·The Journal of Surgical Research·John P DavisGilbert R Upchurch
Nov 30, 2012·The British Journal of Surgery·S SvensjöA Wanhainen
Sep 20, 2011·The British Journal of Surgery·A M ConwayI M Loftus
Apr 5, 2012·The British Journal of Surgery·A AnjumJ T Powell
Oct 7, 2015·Journal of Diabetes and Its Complications·Kalliopi PafiliDimitri P Mikhailidis
Sep 15, 2015·Journal of Vascular Surgery·Jonathan MisskeyDavid Kopriva
Oct 29, 2015·BioMed Research International·Tejas CanchiSriram Narayanan
Jun 1, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S BohlinM Björck
Jan 23, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P De RangoM Lenti
Mar 19, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M RouerR L Dalman
May 9, 2015·The British Journal of Surgery·D P J HowardUNKNOWN Oxford Vascular Study
Nov 12, 2014·Pflügers Archiv : European journal of physiology·Ludovic WaeckelMichel Félétou
Dec 4, 2014·The Lancet. Diabetes & Endocrinology·Anoop Dinesh ShahHarry Hemingway
Jun 28, 2015·Journal of Vascular Surgery·Jussi A HernesniemiTapio Hakala
Oct 29, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Koji KurosawaDai Yamanouchi
May 27, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Sophia G SassaniDimitrios P Sokolis
Nov 27, 2014·The New England Journal of Medicine·K Craig Kent

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