Analysis of risk factors for cutaneous warts in renal transplant recipients

Nephron
A BarbaG C Chieregato

Abstract

We have investigated some possible risk factors for cutaneous warts in a consecutive group of renal transplant recipients treated with three different immunosuppressive regimens: prednisolone + azathioprine (PA), prednisolone + azathioprine + cyclosporin (PAC), prednisolone + cyclosporin (PC). Kaplan and Meier analysis showed an earlier onset of warts in the PAC and PC groups than in the PA group (p < 0.0001), which might be related to the different immunosuppressive action of the pharmacological treatments including cyclosporin. Seven patients had skin cancer: 4 of them also had multiple warts on the cancer site. In 2 patients, histological examination demonstrated the neoplastic transformation of a wart. Maintenance posology of azathioprine, cyclosporin and prednisolone may be an important risk factor for cutaneous warts; on the other hand HLA-B mismatch and HLA-A11 seem to have no effect.

Citations

Feb 19, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Krüger-CorcoranC Ulrich
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·F J MoloneyG M Murphy
Nov 18, 2003·The British Journal of Dermatology·T SchmookE Stockfleth
Aug 3, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Claudio Ponticelli, Pier Luca Bencini
May 21, 2019·International Journal of STD & AIDS·Marco CampoliPietro Rubegni

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