Analysis of scientific truth status in controlled rehabilitation trials

Journal of Evaluation in Clinical Practice
Roger KerryStephen D Mumford

Abstract

Systematic reviews, meta-analyses and clinical guidelines (reviews) are intended to inform clinical practice, and in this sense can be thought of as scientific truthmakers. High-quality controlled trials should align to this truth, and method quality markers should predict truth status. We sought to determine in what way controlled trial quality relates to scientific truth, and to determine predictive utility of trial quality and bibliographic markers. A sample of reviews in rehabilitation medicine was examined. Two scientific truth dimensions were established based on review outcomes. Quality and bibliographic markers were extracted from associated trials for use in a regression analysis of their predictive utility for trial truth status. Probability analysis was undertaken to examine judgments of future trial truth status. Of the 93 trials included in contemporaneous reviews, overall, n = 45 (48%) were true. Randomization was found more in true trials than false trials in one truth dimension (P = 0.03). Intention-to-treat analysis was close to significant in one truth dimension (P = 0.058), being more commonly used in false trials. There were no other significant differences in quality or bibliographic variables between true ...Continue Reading

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Citations

Dec 15, 2015·Journal of Evaluation in Clinical Practice·Rani Lill AnjumStephen D Mumford
Oct 27, 2016·Archives of Physical Medicine and Rehabilitation·Tiago S Jesus
Dec 15, 2018·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Andrew D Benton, David C Benton
Oct 19, 2017·Musculoskeletal Science & Practice·Roger Kerry

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