Analysis of sea star larval regeneration reveals conserved processes of whole-body regeneration across the metazoa

BMC Biology
Gregory A CaryVeronica F Hinman

Abstract

Metazoan lineages exhibit a wide range of regenerative capabilities that vary among developmental stage and tissue type. The most robust regenerative abilities are apparent in the phyla Cnidaria, Platyhelminthes, and Echinodermata, whose members are capable of whole-body regeneration (WBR). This phenomenon has been well characterized in planarian and hydra models, but the molecular mechanisms of WBR are less established within echinoderms, or any other deuterostome system. Thus, it is not clear to what degree aspects of this regenerative ability are shared among metazoa. We characterize regeneration in the larval stage of the Bat Star (Patiria miniata). Following bisection along the anterior-posterior axis, larvae progress through phases of wound healing and re-proportioning of larval tissues. The overall number of proliferating cells is reduced following bisection, and we find evidence for a re-deployment of genes with known roles in embryonic axial patterning. Following axial respecification, we observe a significant localization of proliferating cells to the wound region. Analyses of transcriptome data highlight the molecular signatures of functions that are common to regeneration, including specific signaling pathways and c...Continue Reading

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Citations

Jun 7, 2020·Nature Reviews. Genetics·Joseph A Goldman, Kenneth D Poss
Mar 16, 2019·Science·Andrew R GehrkeMansi Srivastava
Jan 31, 2021·Cellular and Molecular Life Sciences : CMLS·Loïc BideauEve Gazave
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Jul 22, 2021·Annual Review of Cell and Developmental Biology·Mansi Srivastava
Oct 12, 2021·Cell and Tissue Research·Kalacheva Nadezhda VDolmatov Igor Yu

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Methods Mentioned

BETA
amputation
RNA-Seq

Key Resources (RRID) Mentioned

AB_514500
AB_476793
AB_2535766

Software Mentioned

Nanostring nCounter
Trimmomatic
ImageJ
Tophat
Watershed
edgeR
Nanostring
nCounter
R
Nanostring nCounter codeset

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