PMID: 9524290Apr 3, 1998Paper

Analysis of serum cytokine levels in primary biliary cirrhosis patients and healthy adults

Journal of Clinical Laboratory Analysis
M YamashikiF Ichida

Abstract

By using commercially available ELISA kits, serum IL-6 and TNF-alpha levels in healthy adults, and the levels of various cytokines in patients with primary biliary cirrhosis or chronic viral liver diseases, were investigated. IL-6 levels of healthy subjects were distributed in a wide range, and the distribution pattern was similar to those of the patients. TNF-alpha levels tended to be low in females in their 30s, but there were no abnormalities in the patients. Characteristic findings, in the primary biliary cirrhosis patients, were an increase of IFN-gamma and IL-2 levels, and a decrease of GM-CSF levels (P < 0.05). IL-8 levels were higher in the patients than in the healthy subjects (P < 0.05), and the increase was remarkable in chronic viral liver disease patients. We believe that measurement of serum cytokine levels as a clinical immunological test is highly useful. Further development of simpler, more rapid, and more sensitive analysis methods is desired.

Citations

Mar 23, 2000·Journal of Hepatology·R PouponR E Poupon
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Tamara N PereiraGrant A Ramm
Nov 26, 2009·Toxicology and Applied Pharmacology·Katryn AllenBryan L Copple
Nov 6, 2008·Clinics in Liver Disease·Montserrat Moreno, Ramon Bataller

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