Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: its usefulness as a marker of graft-versus-host reaction

American Journal of Hematology
Masayuki NagasawaShuki Mizutani

Abstract

Granulysin is a newly identified CTL/NK cell-related cytotoxic protein, which is secreted in both constitutive and Ca-dependent manner. To evaluate its significance in stem-cell transplantation (SCT), serum granulysin was measured by newly established ELISA method in 26 patients undergoing SCT (21 allogeneic and 5 autologous). In the allogeneic SCT, granulysin was transiently increased in 3 weeks, which was not observed in autologous SCT. In acute GVHD, serum granulysin was markedly increased and correlated with the severity of GVHD. Elevation of granulysin was not necessarily associated with increase of sIL2R or IFN-gamma. In vitro, allospecific T cells released granulysin in an allo-specific manner, and it was correlated with allo-specific cytotoxic activity. These results indicate that increased release of granulysin presents alloreactivity and serum granulysin is useful as a marker of GVHD in SCT.

References

Mar 1, 1987·The Journal of Experimental Medicine·J JongstraA M Krensky
Feb 10, 1999·The Journal of Infectious Diseases·P C WeverI J ten Berge
Aug 17, 1999·The Journal of Clinical Investigation·G R HillJ L Ferrara
Dec 14, 1999·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·M Ito, J A Shizuru
May 3, 2000·The Journal of Clinical Investigation·B NikolicM Sykes
Feb 15, 2001·Nature Medicine·M T OchoaR L Modlin
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K OgawaK Nagata
Nov 12, 2002·Nature Medicine·Cornelius SchmaltzMarcel R M van den Brink
Jul 30, 2003·European Journal of Immunology·Kazuyuki OgawaKinya Nagata

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Citations

Aug 15, 2012·International Journal of Hematology·Nodoka SekiguchiFumihiro Ishida
Sep 17, 2013·Journal of Dermatological Science·Sachiko OnoKenji Kabashima
Jan 12, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jianhua LinWanli Liu
Mar 4, 2009·Tissue Antigens·A M Krensky, C Clayberger
Jan 9, 2010·Histopathology·Nikoletta Nagy, John A McGrath
Nov 17, 2009·British Journal of Haematology·Masayuki NagasawaNorio Shimizu
Mar 24, 2007·Tuberculosis·Diana Di LibertoAlfredo Salerno
Jun 25, 2013·The Journal of Allergy and Clinical Immunology·Chuang-Wei WangShuen-Iu Hung
Jan 15, 2008·International Journal of Hematology·Masayuki NagasawaShuki Mizutani
Oct 12, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Chun-Bing ChenUNKNOWN Taiwan Severe Cutaneous Adverse Reaction Consortium
Mar 9, 2021·International Journal of Hematology·Masayuki NagasawaTomohiro Morio
Aug 28, 2021·World Journal of Transplantation·Masayuki Nagasawa

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