Analysis of serum heat shock protein 70 (HSPA1A) concentrations for diagnosis and disease activity monitoring in patients with rheumatoid arthritis

Cell Stress & Chaperones
Seyed Reza NajafizadehManouchehr Nakhjavani

Abstract

Heat shock proteins (HSPs) have been repeatedly implicated in the pathogenesis of rheumatoid arthritis (RA). The authors aimed to study applicability of heat shock protein 70 (HSPA1A) serum levels as a diagnostic factor and a severity indicator in patients with RA and to quantify cut-off point that predicts status of RA with highest specificity. A total of 76 patients with RA and 36 healthy adults were studied in this case-control analysis. Patients had a higher HSPA1A level than the control group (0.78 ± 0.13 vs. 0.12 ± 0.02 ng/mL, p = 0.006), irrespective of presence of absence of rheumatoid factor or anti-citrullinated cyclic peptide. Next, diagnostic accuracy of the HSPA1A in diagnosis of RA was evaluated (area under curve 0.71; p < 0.05). HSPA1A predicted status of having RA in levels above 0.42 ng/mL with more than 90 % specificity. In addition to diagnostic value, HSPA1A can distinguish between high disease activity (1.66 ± 0.75 ng/mL) and low (0.49 ± 0.1 ng/mL), moderate (0.52 ± 0.12 ng/mL), or remission phase (0.48 ± 0.11 ng/mL). Moreover, patients in remission still had a higher HSPA1A level compared to normal subject (0.48 ± 0.11 vs. 0.12 ± 0.02 ng/mL, p < 0.05). Our results showed that serum HSPA1A could be implemen...Continue Reading

References

Dec 5, 1998·Pharmacology & Therapeutics·J G Kiang, G C Tsokos
Jan 20, 2004·Arthritis and Rheumatism·Christoph SchickInga Melchers
Jan 3, 2006·Journal of Leukocyte Biology·John D Johnson, Monika Fleshner
Apr 14, 2006·Handbook of Experimental Pharmacology·G Multhoff
Jul 9, 2008·Autoimmunity·Lucie SedlackovaIlona Hromadnikova
Jul 30, 2008·Cell Stress & Chaperones·Harm H KampingaLawrence E Hightower
May 25, 2010·Cell Stress & Chaperones·Manouchehr NakhjavaniTiago F Outeiro
Sep 2, 2010·Journal of Neuroscience Research·Hanna CwiklinskaKrzysztof W Selmaj
May 9, 2012·Frontiers in Immunology·Thiago J BorgesWillem van Eden
Aug 28, 2012·Bioinformatics·Ratheesh Kumar RPatrick D'Silva
May 18, 2013·Cell Stress & Chaperones·Afsaneh MortezaAlireza Esteghamati

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Citations

Jul 15, 2016·Rheumatology·Julia Spierings, Willem van Eden
May 3, 2020·Cell Stress & Chaperones·Stefan TukajKrzysztof Sitko
Jul 30, 2020·International Journal of Molecular Sciences·Stefan Tukaj
Mar 13, 2019·International Journal of Environmental Research and Public Health·Declan Timothy Waugh

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