Analysis of serum inflammatory mediators in type 2 diabetic patients and their influence on renal function

PloS One
Liliane Silvano AraújoJuliana Reis Machado

Abstract

To evaluate the serum concentrations of inflammatory mediators in patients with type 2 diabetes mellitus (T2DM) with or without renal alteration (RA) function. Serum samples from 76 patients with T2DM and 24 healthy individuals were selected. Patients with T2DM were divided into two groups according to eGFR (> or < 60mL/min/1.73m2). Cytokines, chemokines and adipokines levels were evaluated using the Multiplex immunoassay and ELISA. TNFR1 and leptin were higher in the T2DM group with RA than in the T2DM group without RA and control group. All patients with T2DM showed increased resistin, IL-8, and MIP-1α compared to the control group. Adiponectin were higher and IL-4 decreased in the T2DM group with RA compared to the control group. eGFR positively correlated with IL-4 and negatively with TNFR1, TNFR2, and leptin in patients with T2DM. In the T2DM group with RA, eGFR was negatively correlated with TNFR1 and resistin. TNFR1 was positively correlated with resistin and leptin, as well as resistin with IL-8 and leptin. Increased levels of TNFR1, adipokines, chemokines and decrease of IL-4 play important role in the inflammatory process developed in T2DM and decreased renal function. We also suggest that TNFR1 is a strong predictor ...Continue Reading

References

Jan 1, 1993·International Review of Experimental Pathology·R ZwahlenA Rot
Feb 12, 1998·The New England Journal of Medicine·A D Luster
Mar 3, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T WadaH Yokoyama
Oct 27, 1999·Metabolism: Clinical and Experimental·B Fruehwald-SchultesA Peters
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Mar 29, 2001·Nature Immunology·C R Mackay
Mar 29, 2001·Nature Immunology·C Gerard, B J Rollins
Feb 24, 2001·Nature·C M SteppanM A Lazar
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R SalcedoJ J Oppenheim
Nov 2, 2001·Biochemical and Biophysical Research Communications·M FasshauerR Paschke
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Juan F NavarroJavier Garca
Sep 3, 2003·Biochemical and Biophysical Research Communications·S KaserJ R Patsch
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·M Crook
May 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Zofia I NiemirStanislaw Czekalski
Dec 4, 2004·PLoS Medicine·Michael LehrkeMitchell A Lazar
Feb 16, 2005·Circulation·Muredach P ReillyDaniel J Rader
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason C O'ConnorGregory G Freund
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria BokarewaAndrej Tarkowski
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi
Jul 26, 2005·Biochemical and Biophysical Research Communications·Nirupama SilswalNasreen Z Ehtesham
Sep 20, 2005·Journal of the American College of Cardiology·Paolo CalabroEdward T H Yeh
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel R JohnsonGregory G Freund
Nov 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Abu R VasudevanChristie M Ballantyne
Jan 6, 2006·Journal of the American Society of Nephrology : JASN·Elena Galkina, Klaus Ley
Jan 25, 2006·Inflammatory Bowel Diseases·Konstantinos KarmirisElias A Kouroumalis
Aug 15, 2006·TheScientificWorldJournal·Juan F Navarro, Carmen Mora
Sep 29, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yvonne Y ShenPhilip W Peake
Oct 17, 2006·Annals of the Rheumatic Diseases·L SenoltM Haluzík
Nov 23, 2006·Cytokine & Growth Factor Reviews·Juan F Navarro, Carmen Mora-Fernández
Jun 6, 2007·Current Diabetes Reports·Michael D Williams, Jerry L Nadler
Nov 27, 2007·FEBS Letters·William P Cawthorn, Jaswinder K Sethi
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Pawel P WolkowAndrzej S Krolewski
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Christopher B GuestGregory G Freund
Feb 25, 2009·Expert Opinion on Therapeutic Targets·Joachim BeigeJürgen Kratzsch
Apr 28, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Luis F RamosT Alp Ikizler
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Feb 9, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chia-Chao WuYuh-Feng Lin

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Citations

Sep 17, 2020·Investigative Ophthalmology & Visual Science·Ayako OkitaKoh-Hei Sonoda
Jun 29, 2021·Biochemistry and Biophysics Reports·Maher M FadelEman Ae Badr
Jul 23, 2021·Translational Oncology·Ankita DebManoj Kumar Bhat

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Methods Mentioned

BETA
blood collection
enzyme-linked immunosorbent assay

Software Mentioned

Excel
GraphPad Prism

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