Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid

Experimental Dermatology
Katja BieberMichael Kasperkiewicz

Abstract

Experimental models of bullous pemphigoid (BP), the most frequent subepidermal autoimmune bullous disease, revealed that the immune response leading to blister formation represents an incompletely understood complex process involving different inflammatory cells. In contrast to previous reports commonly focusing on limited molecular and cellular phenotypes of the disease, the aim of this study was to investigate a broad spectrum of markers of cellular immune activation in patients with BP. We found that serum levels of soluble CD4, myeloperoxidase, S100A12, eosinophil cationic protein and soluble P-selectin were significantly elevated in patients with active BP compared with normal controls. Mast cell tryptase and neopterin serum levels significantly decreased at the time of clinical remission of the patients. Additionally, serum concentrations of soluble IL-2 receptor, mast cell tryptase and soluble P-selectin were significantly associated with levels of circulating anti-BP180 autoantibodies. Our findings confirm and extend previous reports suggesting some concomitant involvement of a panel of molecules representative for a wide spectrum of cellular players (T cells, mast cells, neutrophils, eosinophils, macrophages and platel...Continue Reading

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Citations

Dec 26, 2017·Frontiers in Immunology·Yale LiuYumin Xia
May 16, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·B S Daniel, D F Murrell
Dec 20, 2019·Experimental Dermatology·Maksim V Plikus, Ralf Paus
Jul 25, 2019·Frontiers in Immunology·Xiaobo LiuStefan W Schneider
Nov 22, 2017·Experimental Dermatology·Frank Antonicelli, Ralf J Ludwig
Aug 10, 2017·Frontiers in Medicine·Maria Rosaria GaldieroGianni Marone
Jul 18, 2019·Frontiers in Immunology·Giovanni GenoveseAngelo Valerio Marzano
Jan 29, 2019·Frontiers in Medicine·Hiroshi KogaKatja Bieber
May 28, 2019·Frontiers in Immunology·Kentaro IzumiRalf J Ludwig
Jul 13, 2019·Frontiers in Immunology·Sho HiroyasuDavid J Granville
Oct 7, 2021·Nature Reviews. Immunology·Pavel KolkhirMarcus Maurer
Jun 17, 2020·Panminerva Medica·Virginia A JonesKyle T Amber

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