Analysis of Side Effect Profile of Alopecia, Nail Changes, Peripheral Neuropathy, and Dysgeusia in Prostate Cancer Patients Treated With Docetaxel and Cabazitaxel

Clinical Genitourinary Cancer
Aurelius OmlinSilke Gillessen

Abstract

We hypothesized that the adverse event (AE) profile of cabazitaxel with regard to alopecia, nail changes, neuropathy, and dysgeusia differs from docetaxel. Prospectively collected data on treatment-emergent AEs (frequency and grade [G]) from clinical trial databases of docetaxel every 3 weeks (q3w) (in TAX327 and VENICE) and cabazitaxel q3w (in TROPIC) were analyzed. The frequency of new or worsening AEs (all G and G3-4) for 1301 patients was significantly less for alopecia, nail changes, neuropathy, and dysgeusia for cabazitaxel compared with docetaxel. Treatment with cabazitaxel might cause less alopecia, nail changes, neuropathy, and dysgeusia compared with docetaxel.

References

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Citations

Feb 2, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexander MeiselFrank Stenner-Liewen
Jun 7, 2015·Clinical Genitourinary Cancer·Marie-Claire DesaxSilke Gillessen
Jul 18, 2016·Journal of the Neurological Sciences·W GrisoldW N Löscher
Jun 28, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Sunil Parimi, Kim N Chi
Jan 18, 2018·The Journal of Clinical Investigation·Alix F LeblancShuiying Hu
Aug 27, 2019·Combinatorial Chemistry & High Throughput Screening·Sarah ShinOk-Sun Bang
Oct 11, 2017·Neuro-oncology·Alicia M Zukas, David Schiff
Jun 21, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Glen A Cook
May 10, 2017·Annals of Neurology·Nathan P StaffAnthony J Windebank
Aug 13, 2021·Cancer Medicine·Cedric PobelStéphane Oudard

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