PMID: 2503614Jul 1, 1989Paper

Analysis of site of action of a choriocarcinoma-derived immunoregulatory factor on IL-2-mediated T cell responses

Journal of Reproductive Immunology
N MatsuzakiO Tanizawa

Abstract

We have investigated the functional ability of a choriocarcinoma-cell-derived factor to block human T cell responses and the factor's immunoregulatory site of action on the T cell signal transduction pathway. The factor completely suppressed human T cell responses activated by phorbol ester and calcium ionophore, reagents which strongly stimulate IL-2-mediated T cell responses. It failed to inhibit CD 25 expression and IL-2 production by T cell blasts in the T cell activation phase, but completely blocked recombinant IL-2-induced proliferation of T cell blasts in the T cell proliferation phase. Absorption experiments with the factor and Con A-induced T cell blasts as well as [125I]IL-2 binding experiments with T cell blasts revealed that the factor acted on the physiological events occurring after IL-2-mediated stimulation of IL-2 receptor complexes, demonstrating no interaction of the factor with either IL-2 molecules or IL-2 receptor complexes. Moreover, it suppressed murine IL-2 dependent T cell line proliferation, suggesting the presence of common pathways in human and murine T cell proliferation. The biological and immunological significance of the factor during pregnancy and in the immunosuppressed tumor-bearing hosts are...Continue Reading

References

Aug 1, 1985·Journal of Reproductive Immunology·E NakayamaS Miwa
Jan 15, 1985·American Journal of Obstetrics and Gynecology·S DayaA Chaput
Jan 1, 1987·Journal of the American Academy of Child and Adolescent Psychiatry·A U Khan
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J R LuckasenJ H Kersey
Jun 22, 1984·Science·D A Cantrell, K A Smith

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Citations

Dec 1, 1996·Journal of Reproductive Immunology·G S Vince, P M Johnson
Dec 1, 1990·American Journal of Reproductive Immunology : AJRI·F SajiO Tanizawa
Oct 1, 1994·American Journal of Reproductive Immunology : AJRI·W A BennettB D Cowan
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·W A BennettB D Cowan
Jan 1, 1991·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·D BurtP L Stern

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