Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer

Psychiatric Genetics
Aya InaiYukiko Kano

Abstract

The SLITRK1 (Slit and Trk-like 1) gene has been suggested to be a promising candidate for Tourette syndrome (TS) since the first report that identified its two rare variants adjacent to the chromosome inversion in a TS child with inv(13) (q31.1;q33.1). A series of replication studies have been carried out, whereas the role of the gene has not been elucidated. The present study aimed to determine whether the two or novel nonsynonymous variants were identified in Japanese TS patients and carry out an association analysis of the gene in a Japanese population. We did not observe the two or any novel nonsynonymous variants in the gene. In contrast, a significant difference was observed in the distributions of the haplotypes consisting of rs9546538, rs9531520, and rs9593835 between the patients and the controls. This result may partially support the implication of SLITRK1 in the pathogenesis of TS, warranting further studies of the gene.

References

Jul 1, 1989·Journal of the American Academy of Child and Adolescent Psychiatry·J F LeckmanD J Cohen
Aug 14, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Debora M MirandaCathy L Barr
Nov 17, 2009·Journal of Psychosomatic Research·Julia A O'RourkeDavid L Pauls

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Citations

Feb 24, 2016·Frontiers in Psychiatry·Nawei SunGary A Heiman
Jul 28, 2016·Frontiers in Neuroscience·Luca PagliaroliCsaba Barta
Sep 15, 2020·Frontiers in Neurology·Luca PagliaroliCsaba Barta
Mar 29, 2021·Journal of Molecular Neuroscience : MN·Iman Imtiyaz Ahmed Juvale, Ahmad Tarmizi Che Has

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Methods Mentioned

BETA
PCR
genotyping

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