Analysis of small intestinal transit and colon arrival times of non-disintegrating tablets administered in the fasted state

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Mitja PišlarMarija Bogataj

Abstract

In this study individual data on tablet gastrointestinal transit times (i.e. gastric emptying, small intestinal transit, ileocecal junction residence, and colon arrival times) were obtained from literature in order to present and analyze their distributions and relationships. The influence of the time of food intake after tablet administration in fasted state on gastrointestinal transit times was additionally evaluated. There were 114 measurements from subjects who received the first meal at 4h after tablet administration. Approximately 32% of the tablets arrived into the colon before the meal intake at 4h. An evident increase in the frequency of colon arrival of tablets within 40min after the meal intake at 4h post-dose was observed, where approximately 39% of all tablets arrived into the colon. This is in accordance with findings described in literature where a meal ingested several hours post-dose accelerates tablet transit through the terminal ileum and shortens the transit through the small intestine. The median (min, max) of gastric emptying, small intestinal transit, and colon arrival times in the group where the first meal intake was at 4h post-dose is 35 (0,192), 215 (60,544), and 254 (117,604) minutes, respectively. T...Continue Reading

References

Jan 1, 1989·Nuclear Medicine Communications·M J MundyJ G Hardy
Oct 31, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y S KrishnaiahS Narasimha Rao
Jun 10, 2000·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·D L Guyton
Mar 22, 2001·Advanced Drug Delivery Reviews·I R WildingS S Davis
Jan 17, 2004·International Journal of Pharmaceutics·Kwabena Ofori-KwakyeAnne-Marie Smith
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C-H Malbert
Sep 16, 2005·Drugs·Abdul W Basit
Sep 29, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Luciana A CoráJosé Ricardo de Arruda Miranda
Oct 11, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Werner WeitschiesHubert Mönnikes
Nov 5, 2005·Alimentary Pharmacology & Therapeutics·C SchillerW Weitschies
Jun 3, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G DinningI J Cook
Nov 5, 2008·Pharmaceutical Research·Hala M FaddaAbdul W Basit
Dec 31, 2008·International Journal of Pharmaceutics·L A HodgesH N E Stevens
Jul 22, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Werner WeitschiesHubert Mönnikes
May 19, 2010·International Journal of Pharmaceutics·Kah-Hay Yuen
Jan 26, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F J O VarumA W Basit
Apr 25, 2013·International Journal of Pharmaceutics·F J O VarumA W Basit

❮ Previous
Next ❯

Citations

May 20, 2015·Journal of Pharmaceutical Sciences·Constantinos MarkopoulosChristos Reppas
Jun 29, 2018·Frontiers in Physiology·Fianne L P SipsNatal A W van Riel
Nov 21, 2020·Pharmaceutics·Aravindram Attiguppe SeetharamAfrasim Moin
Feb 17, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leonardo Antonio PintoJosé Ricardo de Arruda Miranda
Jun 20, 2020·Drug Discovery Today·Annemarie BroesderWouter L J Hinrichs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.