Analysis of Small Ubiquitin-Like Modifier (SUMO) Targets Reflects the Essential Nature of Protein SUMOylation and Provides Insight to Elucidate the Role of SUMO in Plant Development

Plant Physiology
Nabil Elrouby

Abstract

Posttranslational modification of proteins by small ubiquitin-like modifier (SUMO) has received much attention, reflected by a flood of recent studies implicating SUMO in a wide range of cellular and molecular activities, many of which are conserved throughout eukaryotes. Whereas most of these studies were performed in vitro or in single cells, plants provide an excellent system to study the role of SUMO at the developmental level. Consistent with its essential roles during plant development, mutations of the basic SUMOylation machinery in Arabidopsis (Arabidopsis thaliana) cause embryo stage arrest or major developmental defects due to perturbation of the dynamics of target SUMOylation. Efforts to identify SUMO protein targets in Arabidopsis have been modest; however, recent success in identifying thousands of human SUMO targets using unique experimental designs can potentially help identify plant SUMO targets more efficiently. Here, known Arabidopsis SUMO targets are reevaluated, and potential approaches to dissect the roles of SUMO in plant development are discussed.

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Citations

Oct 19, 2017·Acta Biochimica Et Biophysica Sinica·Hong ZhaoLinxi Chen
Apr 19, 2017·The Plant Journal : for Cell and Molecular Biology·Ella NukarinenAndreas Bachmair
Dec 23, 2020·Plants·Moumita Srivastava, Ari Sadanandom
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Feb 18, 2021·Plant & Cell Physiology·Justyna ŁabuzWojciech Strzałka
Jun 16, 2021·Plant Cell Reports·Moumita SrivastavaAnjil Kumar Srivastava
Jul 29, 2021·Plant Science : an International Journal of Experimental Plant Biology·Danlu HanChengwei Yang
Jul 22, 2021·The New Phytologist·Csaba PéterAndrás Viczián

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