PMID: 5919558Apr 1, 1966

Analysis of sodium and potassium conductances in the procaine end-plate potential

The Journal of Physiology
T Maeno

Abstract

1. The effect of procaine on neuromuscular transmission was studied on the sartorius muscle of the frog, Rana pipiens, with intracellular microelectrodes.2. Mean quantal content of the e.p.p. in high Mg Ringer was little affected by procaine.3. The short circuit effect of the e.p.p. on the action potential, which was an indication of change in potassium conductance (Deltag(K)) during the e.p.p., was investigated on the muscle fibre immobilized in hypertonic Ringer. It was found that procaine had little effect on Deltag(K).4. The equilibrium potential of the e.p.p. (E(e.p.p.)) was measured in hypertonic Ringer. E(e.p.p.) was 12 mV in control experiment and was decreased to 3.1 mV in 10(-4) procaine. The ratio Deltag(Na)/Deltag(K) was calculated to be 2.75 in control and 2.11 in 10(-4) procaine.5. E.p.p.s were recorded extracellularly to study changes in the time course of Deltag(Na) in procaine. Procaine reduced the peak magnitude of Deltag(Na); following the peak, Deltag(Na) fell quickly to a lower level, which decayed much more slowly.6. An end-plate model with separate sodium and potassium pathways is proposed to explain the procaine e.p.p. Procaine is assumed to affect the time course of Deltag(Na).7. E.p.p.s simulated from ...Continue Reading

Citations

Jan 1, 1978·Progress in Neurobiology·E M Landau
Jan 1, 1969·Acta Anaesthesiologica Scandinavica. Supplementum·R L Katz, A J Gissen
May 1, 1983·Journal of Ethnopharmacology·Y N Singh
Jan 1, 1980·British Journal of Pharmacology·Y HaraH Kuriyama
Feb 1, 1983·British Journal of Pharmacology·E A Connor, R L Parsons
Jan 1, 1971·British Journal of Pharmacology·G D Hirst, D R Wood
Jan 1, 1971·British Journal of Pharmacology·G D Hirst, D R Wood
Apr 27, 1968·Nature·P W Gage, C M Armstrong
Aug 8, 1973·Nature: New Biology·D Paupardin-Tritsch, H M Gerschenfeld
Jul 1, 1974·Quarterly Reviews of Biophysics·H P Rang
Feb 1, 1969·British Journal of Pharmacology·A Bennett, B Fleshler
Jul 1, 1969·Anaesthesia·J C Cookson, W D Paton
May 13, 1999·Journal of Neurophysiology·J DudelH Parnas
Nov 1, 1975·Journal of Theoretical Biology·I Gabrovec Popović

Related Concepts

Salientia
Electric Conductivity
Hypertonic Solutions
Magnesium
Nerve-Muscle Preparation
Potassium
Procaina Serra
Sodium

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