Analysis of sonographic features in the differentiation of fibroadenoma and invasive ductal carcinoma

AJR. American Journal of Roentgenology
P Skaane, K Engedal

Abstract

The purpose of this study was to determine the predictive power of sonographic tumor descriptors in the differentiation of fibroadenoma from invasive ductal carcinoma of the breast. Three hundred thirty-six tumors (142 fibroadenomas and 194 invasive ductal carcinomas) of the breast diagnosed using sonography were prospectively recorded with respect to the shape, contour, echo texture, echogenicity, sound transmission, and surrounding tissue of the tumors. Evaluation included odds and odds ratios of single sonographic features as well as sensitivity, specificity, and positive and negative predictive values of combinations of features. Tumor descriptors were also evaluated using multiple logistic regression analysis after adjustment for age and clinical examination. Irregular shape and contour, extensive hypoechogenicity, shadowing, echogenic halo, and distortion of surrounding tissue were the findings with the highest predictive value of malignancy. A thin echogenic pseudocapsule was the most important sonographic finding predictive of the benign nature of a solid mass. Echo texture was of little value in the differentiation of breast tumors. Age and clinical examination remained important predictors in a clinically referred pat...Continue Reading

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