Analysis of steroid conversion in vitro by testicular tissue as a means of selection of infertile males for gonadotrophic substitution therapy

International Journal of Andrology
A A BergB Kjessler

Abstract

Testicular biopsy specimens from 11 infertile men were incubated in vitro with [3H]progesterone before and during long term gonadotrophic treatment. The main metabolites along the delta-4 metabolic pathway and 20 alpha-dihydro-progesterone were determined and the ratio between 20 alpha-dihydro-progesterone and 17 alpha-hydroxyprogesterone formed in vitro was calculated. In 5 patients with originally high ratios (indicating gonadotrophic understimulation), steroid metabolism changed significantly towards a more stimulated pattern. Three of these patients also showed a significant increase in sperm output and 2 of them fathered children. In 6 patients with an originally low ratio (indicating adequate gonadotrophic stimulation) no change in steroid metabolism in vitro or spermatogenesis was seen during therapy. Thus, this ratio between formed 20 alpha-dihydro-progesterone and 17 alpha-hydroxyprogesterone in vitro seems to be of value in predicting whether gonadotrophic treatment will be of clinical benefit.

References

Feb 1, 1978·Acta Endocrinologica·L J Rodriguez-RigauE Steinberger
May 1, 1978·British Journal of Obstetrics and Gynaecology·U Larsson-CohnL Wallentin
May 1, 1972·The Journal of Clinical Endocrinology and Metabolism·T Yanaihara, P Troen
Apr 1, 1972·Journal of Steroid Biochemistry·W P CollinsI F Sommerville

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Citations

Jan 1, 1987·Scandinavian Journal of Urology and Nephrology·F PeterssonE Varenhorst
Jan 1, 1990·Scandinavian Journal of Urology and Nephrology·M Hammar, A A Berg
Jan 1, 1986·Scandinavian Journal of Urology and Nephrology·M HammarL Plöen
Feb 1, 1991·Journal of Cellular Biochemistry·R V SrinivasR W Compans
Jan 1, 1989·Journal of Andrology·B FredricssonL Plöen

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