Analysis of structural and biological parameters affecting plasmid deletion formation in Bacillus subtilis

Molecular & General Genetics : MGG
J KupschT A Trautner

Abstract

Deletions generated following stimulation by the deletion hot spot of plasmid pHV15-1 were studied in Bacillus subtilis. Nucleotide sequencing showed that deletions extend between short direct repeat sequences. Such direct repeat sequences may have homology to the sequence of the hot spot. Deletion formation is recE-independent, but requires an active exonuclease V (AddAB) enzyme. Other structural parameters like plasmid size and structure influence deletion formation.

References

Aug 1, 1979·European Journal of Biochemistry·M F ShemyakinA V Chestukhin
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M S Meselson, C M Radding
Jan 1, 1975·Molecular & General Genetics : MGG·H J Reif, H Saedler
May 1, 1988·Molecular & General Genetics : MGG·I E MaciagJ C Alonso
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H te RieleS D Ehrlich
Jun 1, 1987·Molecular & General Genetics : MGG·J C AlonsoR H Tailor
Aug 25, 1987·Nucleic Acids Research·J F Viret, J C Alonso
Jul 1, 1988·Journal of Bacteriology·J C AlonsoG Lüder
Jun 1, 1988·Molecular & General Genetics : MGG·B P PeetersG Venema
Jan 1, 1987·Annual Review of Genetics·G R Smith
Jan 1, 1985·Molecular & General Genetics : MGG·J C Alonso, T A Trautner
Jan 1, 1985·Molecular & General Genetics : MGG·J C Alonso, T A Trautner
May 1, 1974·Journal of Medical Microbiology·R W Lacey, I Chopra
Jan 1, 1967·Molecular & General Genetics : MGG·N BiswalT A Trautner
Jul 28, 1968·Journal of Molecular Biology·S RivaA Falaschi
Jan 1, 1971·Molecular & General Genetics : MGG·H C Spatz, T A Trautner
Jan 1, 1971·Zeitschrift für Zellforschung und mikroskopische Anatomie·H G Vullings
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D M Lilley
Nov 1, 1982·Journal of Virology·U CanosiT A Trautner
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M M ZukowskiJ P Lecocq
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B W Glickman, L S Ripley
Jun 1, 1981·Journal of Bacteriology·D M WilliamsP S Lovett
Oct 1, 1957·Journal of Bacteriology·S E LURIA, J W BURROUS
Mar 15, 1955·Proceedings of the National Academy of Sciences of the United States of America·J R Platt

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Citations

Jul 15, 1991·Gene·H Leonhardt, J C Alonso
May 7, 2015·Biotechnology and Bioengineering·Kori L Dunn, Christopher V Rao
May 24, 2015·Nucleic Acids Research·Begoña CarrascoJuan C Alonso
Dec 1, 1992·Molecular & General Genetics : MGG·J C AlonsoT A Trautner
Dec 1, 1991·Microbiological Reviews·J F ViretJ C Alonso
Jul 1, 1991·Journal of Bacteriology·J C AlonsoR H Tailor

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