PMID: 8961548Sep 1, 1996Paper

Analysis of structural variability within two-dimensional biological crystals by a combination of patch averaging techniques and self organizing maps

Ultramicroscopy
Jose-Jesus Fernandez, J M Carazo

Abstract

We study in this work the use of self organizing maps to analyze the structural variability that can be found along two-dimensional crystals of biological macromolecules. Small areas of the crystals, termed "patches" by previous researchers, are used to obtain local average images that are then used as the input of a Self Organizing Map. This procedure allows for a fast and accurate image classification. Multivariate Statistical Analysis is then used on the resulting code vectors producing a very condensed data representation. This methodology is applied to previously studied crystals of bacteriophage phi 29 p10 connector, finding a crystalline heterogeneity probably associated to multilayers in some areas of the crystal.

References

Mar 1, 1993·Ultramicroscopy·M F SchmidM W Tam
Jan 1, 1996·Journal of Structural Biology·R A CrowtherJ M Smith
Oct 1, 1996·Journal of Structural Biology·R MarabiniJ M Carazo

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Citations

Oct 23, 2012·Journal of Structural Biology·Antonio Martinez-SanchezJose-Jesus Fernandez
Feb 5, 2008·IEEE Transactions on Neural Networks·P A Castillo-ValdiviesoG Romero
Jan 8, 1999·Journal of Molecular Biology·W WriggersJ A McCammon

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