Analysis of surgical and MRI factors associated with cerebellar mutism

Journal of Neuro-oncology
Anjali SergeantNina Stein

Abstract

The surgical risk factors and neuro-imaging characteristics associated with cerebellar mutism (CM) remain unclear and require further investigation. Therefore, we aimed to examine surgical and MRI findings associated with CM in children following posterior fossa tumor resection. Using our data registry, we retrospectively collected data from pediatric patients who acquired CM and were matched based on age and pathology type with individuals who did not acquire CM after posterior fossa surgery. The strength of association between surgical and MRI variables and CM were examined using odds ratios (ORs) and corresponding 95% confidence intervals (CIs). A total of 22 patients (11 with and 11 without CM) were included. Medulloblastoma was the most common pathology among CM patients (91%); the remaining 9% were diagnosed with a pilocytic astrocytoma. Tumor attachment to the floor of the fourth ventricle (OR 6; 95% CI 0.7-276), calcification/hemosiderin deposition (OR 7; 95% CI 0.9-315.5), and post-operative peri-ventricular ischemia on MRI (OR 5; 95% CI 0.5-236.5) were found to have the highest measures of association with CM. Our results may suggest that tumor attachment to the floor of the fourth ventricle, pathological calcificatio...Continue Reading

References

Sep 7, 2012·Neuro-oncology·Nicole LawDonald J Mabbott
Apr 27, 2013·AJR. American Journal of Roentgenology·Michael J PlazaGaurav Saigal
Sep 21, 2013·AJNR. American Journal of Neuroradiology·S PerreaultK W Yeom
Oct 1, 2013·Journal of Neurosurgery. Pediatrics·Marina Pitsika, Vassilios Tsitouras
Jan 24, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Rosa Reed-BerendtMatthew C H J Morrall
Apr 17, 2014·Medical Hypotheses·Kirsten Margaretha van Baarsen, Joachim André Grotenhuis
May 17, 2014·AJNR. American Journal of Neuroradiology·S PerreaultK W Yeom
Jul 6, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Zoltan Patay
Aug 11, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iska Moxon-EmreDonald J Mabbott
Oct 1, 2016·NeuroImage. Clinical·Sean D McEvoyChristine L Mac Donald

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Citations

Feb 7, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Heng ZhangYongji Tian
Dec 28, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matheus Fernando Manzolli BallesteroRicardo Santos de Oliveira
Jun 12, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shivaram Avula
Feb 26, 2020·Cancer Metastasis Reviews·Michelle M Kameda-Smith
Dec 29, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Miguel Á Amor-GarcíaMaría Sanjurjo-Sáez
Jun 16, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alice NorisFlavio Giordano
Jun 23, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Narjes AhmadianE W Hoving
Jul 7, 2021·Journal of the Academy of Consultation-Liaison Psychiatry·Alvin KengKathleen Ann Sheehan

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