PMID: 698035Aug 1, 1978Paper

Analysis of synergy between cyclophosphamide therapy and immunity against a mouse tumour

British Journal of Cancer
D M ChassouxI C MacLennan

Abstract

C3H/He and CBA/T6T6 mice which share the H2(k) haplotype were compared for their capacity to survive challenges with the C3H-derived fibrosarcoma BP8. It was found:(1) The tumour grows at the same rate with the same median survival time in matched groups of non-immunized mice from both strains after i.p. injection of tumour cells.(2) Cyclophosphamide (Cyclo) at 10 mg/kg will cure CBA mice which have received i.p. injections of 10(7) BP8, but this dose, and more intensive treatment with this drug, fails to cure C3H mice.(3) Injecting (125)IUdR-labelled tumour cells and counting (125)I loss by whole-mouse counting shows that the cytotoxic effect of Cyclo against BP8 is similar in the 2 mouse strains.(4) Cyclo itself does not cure CBA mice, for viable tumour cells are recoverable from the peritoneal cavity 10 days after CBA mice have received 10(7) BP8 followed by 10 mg/kg Cyclo.(5) CBA mice cured of BP8 ascites by Cyclo treatment will reject further i.p. inocula of BP8.(6) The strength of immunity induced by irradiated BP8 cells was directly related to the length of exposure to this antigen. An important aspect of Cyclo treatment is that it prolongs the period during which immunity may develop.(7) Immunization of CBA mice with he...Continue Reading

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