PMID: 6170719Nov 1, 1981Paper

Analysis of T cell hybridomas. I. Characterization of H-2 and Igh-restricted monoclonal suppressor factors

The Journal of Experimental Medicine
M MinamiM E Dorf

Abstract

Five hybridoma T cell lines were prepared by fusion of second order suppressor T cells (Ts2) with the BW5147 thymoma. The culture supernates from these T cell hybrids contained a factor, TsF2, which specifically suppressed 4-hydroxy-3-nitrophenyl acetyl hapten (NP)-induced cutaneous sensitivity responses. TsF2 activity was observed when the factor was administered during the effector phases of the immune response. TsF2 bears I-J determinants and has binding specificity for NPb idiotypic determinants. TsF2 suppressor activity could be absorbed on antigen-primed H-2-incompatible T cells but cannot suppress H-2-incompatible mice. In addition to this H-2 restriction, which maps to the I-J subregion, monoclonal TsF2 also has an Igh genetic restriction. The present results are combined with previous data to describe the cellular interactions leading to immune suppression.

References

Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K OkudaM E Dorf
Jan 1, 1981·Scandinavian Journal of Immunology·B Benacerraf, R N Germain

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Citations

Jan 1, 1995·Immunologic Research·R M O'Hara
Dec 18, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Varuna R AluvihareAlexander G Betz
Oct 29, 1982·Journal of Immunological Methods·D E ColwellS M Michalek
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·M A Miles
Dec 1, 1987·Veterinary Immunology and Immunopathology·H Wigzell
May 1, 1989·Research in Immunology·M Taniguchi
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J LeW Prensky
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S MiyataniT Tada
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V K KuchrooM E Dorf
Aug 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
Nov 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
May 1, 1983·The Journal of Experimental Medicine·M MinamiM E Dorf
Jun 1, 1983·The Journal of Experimental Medicine·I AokiM E Dorf
Aug 1, 1986·Kidney International·E G NeilsonR Mann
Mar 1, 1988·Molecular and Cellular Probes·R I Lechler
Jan 1, 1982·Annals of the New York Academy of Sciences·B BenacerrafM E Dorf
Jan 1, 1987·Annals of the New York Academy of Sciences·A R Pachner, F S Kantor
Jan 1, 1983·Annals of the New York Academy of Sciences·C J Bellone, S Jayaraman
Apr 1, 1985·Immunological Reviews·M E Dorf, B Benacerraf
Aug 1, 1988·International Reviews of Immunology·M E DorfR M O'Hara
Apr 1, 1988·International Reviews of Immunology·R E ConeD R Green
Jan 1, 1985·International Journal of Dermatology·K Nishioka
Mar 1, 1986·Infection and Immunity·R L MosleyR A Cox

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