PMID: 6172534Dec 1, 1981Paper

Analysis of T cell hybridomas. II. Comparisons among three distinct types of monoclonal suppressor factors

The Journal of Experimental Medicine
K OkudaM E Dorf

Abstract

Five hybridoma T cell lines were prepared by fusion of Ts3 cells with the BW 5147 thymoma. The culture supernatants from these T cell hybrids contained a factor, TsF3, which specifically suppressed 4-hydroxy-3-nitrophenyl acetyl hapten (NP(-hapten cutaneous sensitivity responses. The properties of this new series of hybridoma factors was compared with those of two previously characterized types of NP-specific suppressor factors (TsF1 and TsF2). TsF3 activity was only observed if the factor was administered during the effector phases of the immune response. TsF3 bears I-J and C57BL anti-NP antibody idiotypic determinants and has binding specificity for the NP hapten. Furthermore, TsF3 does not suppress H-2 (I-J)-incompatible mice. In addition to this H-2 restriction, the monoclonal TsF3 factors also demonstrated an Igh genetic restriction. Finally, the TsF3 factors could be distinguished by their ability to suppress cyclophosphamide-treated recipients.

References

Aug 3, 1978·Nature·S KontiainenM Feldmann
Jan 1, 1981·Scandinavian Journal of Immunology·B Benacerraf, R N Germain

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Citations

Apr 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·A D ChernousovB D Brondz
Jan 1, 1995·Immunologic Research·R M O'Hara
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S M HedrickY Kaufmann
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V K KuchrooM E Dorf
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·H GomiK Ishizaka
Aug 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
Aug 1, 1982·The Journal of Experimental Medicine·L L Perry, M I Greene
Nov 1, 1982·The Journal of Experimental Medicine·M MinamiM E Dorf
May 1, 1983·The Journal of Experimental Medicine·M MinamiM E Dorf
Feb 1, 1984·The Journal of Clinical Investigation·A Saxon, E Barnett
Aug 1, 1988·International Reviews of Immunology·M E DorfR M O'Hara
Jan 1, 1982·Annals of the New York Academy of Sciences·B BenacerrafM E Dorf
Jan 1, 1983·Annals of the New York Academy of Sciences·C J Bellone, S Jayaraman
Apr 1, 1988·International Reviews of Immunology·R E ConeD R Green
Jan 1, 1985·International Journal of Dermatology·K Nishioka
Nov 27, 1991·Biochemical and Biophysical Research Communications·C L BristowP M Flood

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