Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic

Human & Experimental Toxicology
R BiswasAshok K Giri

Abstract

Over six million people in nine districts of West Bengal, India are exposed to very high levels of arsenic primarily through their drinking water. More than 300,000 people showed arsenic-induced skin lesions in these districts. This is regarded as the greatest arsenic calamity in the world. Chronic arsenicosis causes varied dermatological signs ranging from pigmentation changes, hyperkeratosis to non-melanocytic cancer of skin, and also malignancies in different internal organs. Higher incidences of opportunistic infections are found in the arsenic-exposed individuals, indicating that their immune systems may be impaired somehow. We have thus investigated the effect of arsenic on T-cell proliferation and cytokine secretion in 20 individuals with arsenic-induced skin lesions and compared the results with 18 arsenic-unexposed individuals. A marked dose-dependent suppression of Concanavalin A (Con A) induced T-cell proliferation was observed in the arsenic-exposed individuals compared with the unexposed (P < 0.001) individuals. This correlated with a significant decrease in the levels of secreted cytokines by the T cells (TNF-alpha, IFN-gamma, IL2, IL10, IL5, and IL4) in the exposed individuals (P < 0.001). Thus it can be inferred...Continue Reading

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Citations

Jun 11, 2009·Journal of Clinical Immunology·Nilanjana BanerjeeAshok K Giri
Sep 6, 2013·Environmental Health : a Global Access Science Source·Nygerma L DanglebenMartyn T Smith
Oct 14, 2010·Environmental Health Perspectives·Sultan AhmedRubhana Raqib
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Meghan R PerryAlan H Fairlamb
Jul 11, 2009·Environmental Health Perspectives·Carolyn J MattinglyAntonio Planchart
Jun 14, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sultan AhmedMarie Vahter
Feb 15, 2016·Current Environmental Health Reports·Daniele FerrarioThomas Hartung
Jan 23, 2014·Cutaneous and Ocular Toxicology·Ramesh Chandra GuptaShalini Mohan
Sep 15, 2011·The Kaohsiung Journal of Medical Sciences·Chih-Hung LeeHsin-Su Yu
Jan 13, 2015·Toxicology and Applied Pharmacology·Y S LeeH S Jun
Jan 21, 2016·Ophthalmic Epidemiology·Ratnesh RanjanRamesh Chandra Gupta
May 24, 2012·Toxicology and Applied Pharmacology·Claudie MorzadecLaurent Vernhet
Jan 27, 2009·Toxicology Letters·Rubhana RaqibMarie Vahter
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Aug 26, 2018·The Journal of Dermatology·Sebastian YuHsin-Su Yu
Feb 8, 2018·Current Environmental Health Reports·Lisa Smeester, Rebecca C Fry

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