Analysis of tablet compaction. I. Characterization of mechanical behavior of powder and powder/tooling friction

Journal of Pharmaceutical Sciences
J C CunninghamA Zavaliangos

Abstract

In this first of two articles on the modeling of tablet compaction, the experimental inputs related to the constitutive model of the powder and the powder/tooling friction are determined. The continuum-based analysis of tableting makes use of an elasto-plastic model, which incorporates the elements of yield, plastic flow potential, and hardening, to describe the mechanical behavior of microcrystalline cellulose over the range of densities experienced during tableting. Specifically, a modified Drucker-Prager/cap plasticity model, which includes material parameters such as cohesion, internal friction, and hydrostatic yield pressure that evolve with the internal state variable relative density, was applied. Linear elasticity is assumed with the elastic parameters, Young's modulus, and Poisson's ratio dependent on the relative density. The calibration techniques were developed based on a series of simple mechanical tests including diametrical compression, simple compression, and die compaction using an instrumented die. The friction behavior is measured using an instrumented die and the experimental data are analyzed using the method of differential slices. The constitutive model and frictional properties are essential experimental...Continue Reading

References

Jul 6, 2004·Journal of Pharmaceutical Sciences·I C SinkaA Zavaliangos

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Citations

Jan 22, 2013·Pharmaceutical Research·Gerard Klinzing, Antonios Zavaliangos
May 5, 2011·AAPS PharmSciTech·Simo Matti SiiriäJouko Yliruusi
May 9, 2014·International Journal of Pharmaceutics·Vincent MazelPierre Tchoreloff
Oct 13, 2011·Drug Development and Industrial Pharmacy·Sameh Abdel-HamidGabriele Betz
Sep 8, 2010·Drug Development and Industrial Pharmacy·K GiryD Chulia
May 21, 2014·Journal of Pharmaceutical Sciences·Mingda BiFrancisco Alvarez
Jul 31, 2013·Journal of Pharmaceutical Sciences·Yoshihiro HayashiKozo Takayama
Apr 25, 2007·Journal of Pharmaceutical Sciences·Xiaorong HeGregory E Amidon
Jul 6, 2004·Journal of Pharmaceutical Sciences·I C SinkaA Zavaliangos
Feb 1, 2006·Journal of Pharmaceutical Sciences·D M Kremer, B C Hancock
Apr 19, 2011·International Journal of Pharmaceutics·Sameh Abdel-Hamid, Gabriele Betz
Sep 29, 2009·International Journal of Pharmaceutics·Bruno C HancockRahul Bharadwaj
Jul 19, 2015·International Journal of Pharmaceutics·Ryoichi FurukawaShinji Narisawa
Sep 28, 2015·International Journal of Pharmaceutics·Emmi PalomäkiJouko Yliruusi
Oct 25, 2016·International Journal of Pharmaceutics·V MazelP Tchoreloff
Oct 31, 2007·Journal of Pharmaceutical Sciences·Antonios ZavaliangosDenita Winstead
Jul 3, 2018·Chemical & Pharmaceutical Bulletin·Yoshihiro HayashiYoshinori Onuki
Jun 2, 2005·Pharmaceutical Development and Technology·Marylène VianaDominique Chulia
Mar 5, 2021·Journal of Pharmaceutical Sciences·Shubhajit Paul, Yin-Chao Tseng
Mar 5, 2021·International Journal of Pharmaceutics·Shubhajit PaulYin-Chao Tseng
Jun 30, 2019·International Journal of Pharmaceutics·Vincent MazelPierre Tchoreloff
Dec 24, 2018·Molecular Pharmaceutics·Chengbin HuangYongchao Su
Sep 28, 2021·Journal of Pharmaceutical Sciences·Biplob MitraSy-Juen Wu

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