Analysis of tablet compaction. II. Finite element analysis of density distributions in convex tablets

Journal of Pharmaceutical Sciences
I C SinkaAntonios Zavaliangos

Abstract

A Drucker-Prager/cap constitutive model, where the elastic and plastic model parameters are expressed as a function of relative density (RD), was presented in a companion article together with experimental calibration procedures. Here, we examine the RD distribution in curved-faced tablets with special reference to the die wall lubrication conditions. The compaction of powders is examined using finite element analysis, which involves the following factors: constitutive behavior of powder, friction between powder and tooling, geometry of die and punches, sequence of punch motions, and initial conditions that result from die fill. The predictions of the model are validated using experimental RD maps. It is shown that different die wall lubrication conditions induce opposite density distribution trends in identical tablets (weight, height, and material). The importance of the internal tablet structure is illustrated with respect to break force, failure mode, and friability: it is demonstrated that for a given average tablet density the break force and failure mode are not unique. Also, tablet regions having lower density locally have higher propensity for damage. The applicability of finite element analysis for optimizations of fo...Continue Reading

References

May 8, 2004·International Journal of Pharmaceutics·I C SinkaJ C Cunningham
Jul 6, 2004·Journal of Pharmaceutical Sciences·J C CunninghamA Zavaliangos

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Citations

May 5, 2011·AAPS PharmSciTech·Simo Matti SiiriäJouko Yliruusi
Mar 31, 2011·Drug Development and Industrial Pharmacy·Sameh Abdel-Hamid, Gabriele Betz
Jul 6, 2004·Journal of Pharmaceutical Sciences·J C CunninghamA Zavaliangos
Feb 1, 2006·Journal of Pharmaceutical Sciences·D M Kremer, B C Hancock
Dec 15, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marten KlukkertClaudia S Leopold
Jan 10, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andres M Miguélez-MoránJonathan P K Seville
May 30, 2015·AAPS PharmSciTech·Özgür KeleṣKeith J Bowman
Jul 23, 2015·International Journal of Pharmaceutics·Harona DiarraPierre Tchoreloff
Aug 4, 2011·Pharmaceutical Development and Technology·Sameh Abdel-Hamid, Gabriele Betz
Mar 1, 2015·International Journal of Pharmaceutics·Frederick Osei-Yeboah, Changquan Calvin Sun
Oct 25, 2016·International Journal of Pharmaceutics·V MazelP Tchoreloff
Feb 1, 2017·Journal of Pharmaceutical Sciences·Luca CastratiPierre Tchoreloff
Oct 31, 2007·Journal of Pharmaceutical Sciences·Antonios ZavaliangosDenita Winstead
Jul 3, 2018·Chemical & Pharmaceutical Bulletin·Yoshihiro HayashiYoshinori Onuki
Mar 5, 2021·Journal of Pharmaceutical Sciences·Shubhajit Paul, Yin-Chao Tseng
Dec 24, 2018·Molecular Pharmaceutics·Chengbin HuangYongchao Su
Oct 19, 2020·International Journal of Pharmaceutics·Joelle NassarRichard Elkes

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