PMID: 3754476Feb 26, 1986Paper

Analysis of temporal and dose-dependent effects of estrogen on monoamines in brain nuclei

Brain Research
Kenneth J Renner, V N Luine

Abstract

Levels of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) were measured in hypothalamic and limbic nuclei of ovariectomized rats after various doses of estradiol and at various intervals after estradiol administration. Of 13 areas examined, time- and dose-dependent effects of estrogen on monoamine content were restricted to only a few, discrete areas which concentrate estradiol. Subcutaneous administration of 1-50 micrograms of estradiol benzoate (EB) and measurement of monoamines 24 h later was associated with dose-dependent increases of NE in the medial preoptic nucleus, diagonal band nucleus and periventricular area of the anterior hypothalamus, and increased levels of DA in the periventricular area of the preoptic area. No changes were found in 5-HT levels, but dose-dependent increases in the level of the 5-HT metabolite, 5-hydroxyindole acetic acid (5-HIAA), were measured in the lateral portion of the ventromedial nucleus. Effects of 5 micrograms of EB were evaluated at 1.5, 6, 12 and 45 h after administration. No changes were noted at 1.5 h, but 5-HIAA in the ventromedial nucleus was elevated at 6 and 12 h. NE levels were elevated at 12 and 45 h in the diagonal band and preoptic nuclei and at 45 h in the lateral s...Continue Reading

References

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Citations

Apr 1, 1988·Journal of in Vitro Fertilization and Embryo Transfer : IVF·B BourritE Stiksa
Jan 15, 1993·Experientia·S PajovićJ V Martinović
Mar 5, 1999·Molecular Neurobiology·C L BetheaZ N Lu
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Apr 1, 1986·Brain Research Bulletin·K J RennerV N Luine
Aug 1, 1992·Brain Research Bulletin·V A Dorce, J Palermo-Neto
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Apr 3, 2009·Neurobiology of Learning and Memory·Russ E Carpenter, Cliff H Summers

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