PMID: 16867797Jan 1, 1983

Analysis of the 1,4-benzodiazepines by methods based on hydrolysis

Journal of Pharmaceutical and Biomedical Analysis
J Gasparic, J Zimák

Abstract

The analytical applications of the hydrolysis of 1,4-benzodiazepines to the corresponding benzophenone derivatives are reviewed according to the analytical methods used for their final determination. The scope and limitations of the individual methods for the hydrolysis products are discussed: Colour reactions, photometry, fluorimetry, thin-layer chromatography, gas chromatography and high-performance liquid chromatography. Published data on the kinetic parameters and mechanisms are summarized in an attempt to explain the problems involved in exploiting this reaction for analytical applications.

References

Jun 8, 1976·Archives of Toxicology·G de GrootH H Lemmens
Aug 1, 1976·Journal of Pharmaceutical Sciences·W W HanD D Maness
Jun 1, 1977·Journal of Pharmaceutical Sciences·W W HanD D Maness
Feb 1, 1975·Journal of Pharmaceutical Sciences·H V MauldingA F Michaelis
Apr 1, 1975·Journal of Pharmaceutical Sciences·D D Maness, G J Yakatan
Oct 1, 1975·Journal of Pharmaceutical Sciences·D J Hoffman, A H Chun
Dec 1, 1977·Journal of Pharmaceutical Sciences·W H HongD H Szulczewski
Oct 30, 1974·Journal of Chromatography·D M Hailey
Dec 1, 1974·Journal of Pharmaceutical Sciences·J A de SilvaC V Puglisi
Jan 1, 1972·The Journal of Pharmacy and Pharmacology·F MarcucciS Garattini
Sep 1, 1974·Journal of Pharmaceutical Sciences·G SteinerJ T Carstensen
Oct 1, 1974·Forensic Science·J S Oliver, H Smith
Jan 1, 1972·Journal of the British Endodontic Society·T H Simpson, E Natkin
Apr 1, 1973·Journal of Pharmaceutical Sciences·J P ViauF J Di Carlo
Jun 1, 1973·Journal of Chromatography·D J Berry, J Grove
Sep 1, 1973·Analytical Chemistry·A FrigerioG Belvedere
Apr 1, 1973·Analytical Chemistry·J A de SilvaN Strojny
Jul 26, 1972·Journal of Chromatography·G P BeharrellM K McLaurin
Jul 8, 1971·Journal of Chromatography·A ForgioneG JOMMI
Jul 1, 1966·Journal of Pharmaceutical Sciences·J A de SilvaG Bader
Mar 1, 1970·Journal of Pharmaceutical Sciences·F J DiCarlo, J P Viau
Jan 1, 1971·Journal of Pharmaceutical Sciences·W Sadée, E Van der Kleijn
Aug 1, 1965·Archives of Biochemistry and Biophysics·H W RueliusH E Alburn
Jan 1, 1967·Protoplasma·K H Beyer, J E Baer
Jun 1, 1981·Journal of Pharmaceutical Sciences·W H Hong, D H Szulczewski
May 1, 1980·Journal of Analytical Toxicology·H W Peel, B J Perrigo
Nov 1, 1980·Journal of Pharmaceutical Sciences·N Inotsume, M Nakano
Dec 1, 1994·Cellular and Molecular Neurobiology·D O CarpenterN Hori
Nov 1, 1964·Archives of Biochemistry and Biophysics·G JOMMIM A SILANOS
Dec 1, 1964·Archives of Biochemistry and Biophysics·G JOMMIM A SILANOS
Oct 1, 1964·Journal of Pharmaceutical Sciences·S S WALKENSTEINR A CORRADINO
Mar 12, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleftherios P MamounasNorman Wolmark
Nov 13, 1965·British Medical Journal·R S Pearson

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