Analysis of the acidity index and integrated intragastric acidity in 645 patients presenting with gastroesophageal reflux disease symptoms

Scandinavian Journal of Gastroenterology
Wojciech C BlonskiDavid C Metz

Abstract

In a recent study of patients receiving proton-pump inhibitor (PPI) therapy, a new parameter, the acidity index, was described as being less complicated to calculate and of comparable accuracy (r = 0.93) to integrated intragastric acidity (IA) in assessing intragastric pH control. The aim of this study was to correlate AI with IA using a large database of ambulatory 24-h pH-metry studies in untreated patients presenting with gastroesophageal reflux disease (GERD) symptoms. We retrospectively analyzed 645 studies obtained from 1995 to 2001. Daytime (0800 h-2200 h), night-time (2200 h-0800 h) and 24-h IA and AI were calculated according to age, gender and the presence or absence of GERD, and correlations between these parameters were assessed using linear regression with F-statistic values, p-values and Akaike's Information Criterion values. GERD was defined as total esophageal pH time <4.0, 5 cm above the lower esophageal sphincter, for > or =4.2% of the day. IA and AI were calculated as follows: IA (mmol x h/l) = summation operator(acid in mmol/l at time "t" + acid in mmol/l at time "t - 1")/2 x ("t"-"t - 1"); AI = (%time pH < 4-%time pH < 3) x 1+(%time pH < 3-%time pH < 2) x 10+(%time pH < 2-%time pH < 1) x 100 + (%time pH < 1...Continue Reading

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Citations

May 4, 2013·Alimentary Pharmacology & Therapeutics·D H WeinsteinS A Wank
Jul 6, 2011·Alimentary Pharmacology & Therapeutics·K RaviD A Katzka
May 31, 2006·Gastrointestinal Endoscopy·Taketo YamaguchiHiromitsu Saisho
Oct 18, 2008·European Journal of Clinical Pharmacology·Julia KirchheinerJürgen Brockmöller
May 3, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Jérôme R LechienPiero Marco Fisichella

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