PMID: 7017296Apr 1, 1981Paper

Analysis of the age-related refractoriness of T-lymphocyte reactivity in humans

Mechanisms of Ageing and Development
G BátoryG G Petrányi

Abstract

Aged individuals could be divided into two groups according to their T-lymphocyte transformation values. The relationship between the PHA (phytohemagglutinin) stimulation indices and spontaneous thymidine incorporation; the PHA dose-response type distribution and the relative number of resting T lymphocytes was similar to the control group in aged subjects of seemingly intact T lymphocyte transformation values. However, their B cell compartment was found to be reduced. On the other hand, the ratio between the stimulation indices and spontaneous thymidine incorporation values of aged subjects of impaired T lymphocyte reactivity deviated from that of the control group. This group had an increased frequency of subjects giving maximal transformation values at relatively high PHA doses (hyposensitives) at the expense of normosensitives and showed reduced numbers of resting T cells, but normal B cell compartment. These results suggest that immunodeficiencies developing with age can possibly be of individually different types.

References

Dec 1, 1975·The Journal of Clinical Investigation·D A Horwitz, P I Lobo
Aug 1, 1977·European Journal of Immunology·J R KaldenJ P Cesarini
Aug 17, 1974·Lancet·I C Roberts-ThomsonI R Mackay
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D P StitesH H Fudenberg
Aug 1, 1972·The Journal of Clinical Investigation·E M ShevachI Green
Jan 1, 1973·Transplantation Reviews·Z Bentwich, H G Kunkel
Jun 1, 1981·Immunobiology·G BátoryG G Petrányi

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Citations

Apr 1, 1984·Mechanisms of Ageing and Development·D ZharharyH E Gershon
Sep 1, 1982·Archives of Gerontology and Geriatrics·G BátoryG G Petrányi
Jul 1, 1984·Archives of Gerontology and Geriatrics·G BátoryE Lengyel
Oct 1, 1985·Archives of Gerontology and Geriatrics·G BátoryM Benzur
Aug 1, 1983·Human Immunology·G BátoryG G Petrányi
Mar 18, 2008·Journal of Athletic Training·R Tyler HamiltonDavid H Perrin

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