Analysis of the albino-locus region of the mouse. II. Mosaic mutants.

Genetics
L B Russell

Abstract

Among 119 mutations involving the c locus that were recovered in the course of mouse specific-locus experiments with external radiations, 16 were found in mosaic, or fractional, mutants. The number of additional c-locus fractionals that could have occurred in these experiments and, for a variety of reasons, might not have been clearly identified, probably does not exceed the present number.-There was no evidence for radiation induction of the fractionals, and even those occurring in the irradiated groups may thus be assumed to be of spontaneous origin. Since only two mutations in the control groups were found in whole-body mutants, it appears that the bulk of spontaneous c-locus mutations are fractionals.-None of the mutations recovered in fractional mutants was homozygous lethal; 25% were viable intermediate alleles, and the remainder were albino-like mutants, all viable except for one subvital and one not tested.-Genetic tests of the fractionals indicated no major selection against the new mutations, either gametically or in the progeny.-For the group of fractionals as a whole, about one-half of the germinal tissue carried the mutation, indicating that the fractionals came from an overall blastomere population that was one-ha...Continue Reading

Citations

May 1, 1980·Mutation Research·L B Russell, B E Matter
Aug 27, 2005·Theoretical Biology & Medical Modelling·Chang-Jiang ZhengSuresh H Moolgavkar
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·L B Russell, W L Russell
Dec 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B Holdener-KennyT Magnuson
Sep 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I J Jackson

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