Oct 1, 1977

Analysis of the alloimmune properties of a recombinant genotype in the major histocompatibility complex of the chicken

European Journal of Immunology
M VilhelmováJ Hartmanová


In a population of (CB X CC)F1 X WB hybrids, a chicken was found with a presumably recombinant haplotype, BR1, whose antigenic products detectable by hemagglutination contained determinants derived from both parental haplotypes, i.e. B1 (from CB) and B2 (from CC). This recombinant bird and its progeny from different crosses were tested by skin grafting, graft-vs.-host (GVH) and mixed lymphocyte reactions (MLR). The results define two regions of the B system, the B-F and the B-G. The B-F region determined serologically defined antigens, histocompatibility antigens, and controlled the GVH and MLR reactions, while the B-G region was responsible only for synthesis of serologically detectable antigens.

  • References5
  • Citations13


Mentioned in this Paper

Antigenic Specificity
Lymphocyte Culture Test, Mixed
Recombination, Genetic
Graft Vs Host Reaction
Transplantation, Homologous
SD Antigens
Skin Transplantation

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.