Oct 1, 1977

Analysis of the alloimmune properties of a recombinant genotype in the major histocompatibility complex of the chicken

European Journal of Immunology
M VilhelmováJ Hartmanová

Abstract

In a population of (CB X CC)F1 X WB hybrids, a chicken was found with a presumably recombinant haplotype, BR1, whose antigenic products detectable by hemagglutination contained determinants derived from both parental haplotypes, i.e. B1 (from CB) and B2 (from CC). This recombinant bird and its progeny from different crosses were tested by skin grafting, graft-vs.-host (GVH) and mixed lymphocyte reactions (MLR). The results define two regions of the B system, the B-F and the B-G. The B-F region determined serologically defined antigens, histocompatibility antigens, and controlled the GVH and MLR reactions, while the B-G region was responsible only for synthesis of serologically detectable antigens.

  • References5
  • Citations13

Citations

Mentioned in this Paper

Antigenic Specificity
Lymphocyte Culture Test, Mixed
Recombination, Genetic
Graft Vs Host Reaction
Transplantation, Homologous
SD Antigens
Skin Transplantation

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