PMID: 3613602Jul 1, 1987Paper

Analysis of the antidepressant phenelzine in brain tissue and urine using electron-capture gas chromatography

Journal of Pharmacological Methods
T S RaoG A Torok-Both


A novel gas chromatographic method for the analysis of the antidepressant phenelzine has been developed. The procedure involves extraction with a liquid ion-pairing compound, back-extraction with HCl, basification, and derivatization with pentafluorobenzoyl chloride. The dipentafluorobenzoyl derivative (structure confirmed by mass spectrometry) is separated and analyzed on a gas chromatograph equipped with a fused silica capillary column and an electron-capture detector. The procedure has been utilized for quantitation of phenelzine in brain of phenelzine-treated rats and in urine from human subjects receiving phenelzine.


Jun 8, 2001·Journal of Pharmacological and Toxicological Methods·M SalsaliG B Baker
Apr 1, 1997·Journal of Pharmacological and Toxicological Methods·S RotzingerG B Baker
Feb 26, 2000·Journal of Pharmacological and Toxicological Methods·M SalsaliG B Baker

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