Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test

Genes and Immunity
N TsuchiyaK Tokunaga

Abstract

A number of studies reported associations of HLA-DRB1, TNFalpha (TNF) promoter and TNF receptor II (TNFR2, TNFRSF1B) polymorphisms with systemic lupus erythematosus (SLE), however, the results have often been inconsistent. Such lack of consistency could partly derive from the population admixture involved in the case-control study. To avoid such a problem, polymorphisms in these genes were analyzed using transmission disequilibrium test (TDT) in Caucasian SLE families. Ninety-one Caucasian SLE family samples recruited in southern California were analyzed for the association with HLA-DRB1, TNF promoter positions at -1031, -863, -857 and -308, and TNFR2-196M/R polymorphisms. Significant transmission was observed for HLA-DRB1*1501, but not for HLA-DRB1*0301, nor for TNF haplotype that codes for -308A. Interestingly, TNF haplotype coding for -1031C, -863A, -857C showed a tendency of preferential nontransmission in the patients without lupus nephritis and in those with malar rash. No transmission distortion was observed for TNFR2-196R allele. These findings confirmed the association of HLA-DRB1*1501, but did not replicate that of the HLA-DRB1*0301, TNFA-308A and TNFR2-196R with SLE in this population. In addition, a possible disease...Continue Reading

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Citations

Nov 5, 2003·Trends in Immunology·Betty P Tsao
Aug 18, 2004·Current Opinion in Rheumatology·Betty P Tsao
Nov 14, 2007·Annals of the Rheumatic Diseases·Corinne Miceli-RichardXavier Mariette
Dec 21, 2002·Immunological Reviews·Naoyuki TsuchiyaKatsushi Tokunaga
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Patricia LópezAna Suárez
Jul 20, 2002·Current Rheumatology Reports·Betty P Tsao
Jul 29, 2009·Immunogenetics·Maria WilbeGöran Andersson
Aug 21, 2014·Kidney International·Rafia S Al-Lamki, Tanya N Mayadas
May 14, 2009·Kidney International·Thomas Ernandez, Tanya N Mayadas
Sep 20, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jian ZhaoAntonio La Cava
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Aug 4, 2007·Analytical and Bioanalytical Chemistry·Christian WolfAntonios Kyriakopoulos
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Jan 18, 2006·BMC Health Services Research·Frances C WrightAndrew J Smith
Mar 6, 2007·Seminars in Nephrology·Laurence Morel

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