Analysis of the association of leptin and adiponectin concentrations with metabolic syndrome in children: Results from the IDEFICS study

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Annunziata NappoP Russo

Abstract

Adipokines may play a role in the pathogenesis of the metabolic syndrome (MetS) in children. We aimed to evaluate the association of leptin, adiponectin, and its ratio (L/A ratio) with the metabolic syndrome (MetS) in a subsample of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) cohort. Leptin, adiponectin and MetS parameters were measured in a subsample of 1253 children (3-9.9 years) participating to the IDEFICS study, grouped as: Non-OW (underweight/normal weight) and OW/Ob (overweight/obese). MetS was defined using the sex- and age-specific cut-offs based on the distribution of MetS components in the IDEFICS cohort. The prevalence of the MetS among OW/Ob was 24.8% and 27.1% in boys and girls respectively, whereas ≤2% among Non-OW. OW/Ob had significantly higher leptin and L/A ratio as compared to Non-OW. Significantly higher leptin was found in OW/Ob with MetS as compared with OW/Ob without MetS. Significantly lower adiponectin was observed only in OW/Ob girls as compared to Non-OW. A 1SD increase in leptin and L/A ratio z-scores or a 1SD decrease in adiponectin z-score were significantly associated with higher risk of MetS. After adjustment for BMI or bod...Continue Reading

Citations

Nov 28, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alexis ShubMartha Lappas
Mar 1, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yi-de YangJun Ma
Jul 3, 2019·International Journal of Molecular Sciences·Antonina OrlandoSimonetta Genovesi
Dec 18, 2019·Pediatric Diabetes·Christine Frithioff-BøjsøeJens-Christian Holm
Nov 15, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Charumathi Baskaran, Nurgun Kandemir
Jul 4, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Caroline Abud Drumond CostaPedro Celiny Ramos Garcia
Aug 26, 2020·Hormones and Behavior·Sarah WarkentinAndreia Oliveira
Dec 18, 2021·American Journal of Perinatology·Jessica PippenUNKNOWN Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network

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