Analysis of the bending behaviour of porcine xenograft leaflets and of natural aortic valve material: bending stiffness, neutral axis and shear measurements

Journal of Biomechanics
I Vesely, D Boughner

Abstract

Flexibility of the materials used in the construction of bioprosthetic heart valves is essential for proper valve operation. We therefore examined the bending behaviour of glutaraldehyde treated porcine aortic valve cusps in comparison with fresh aortic valve tissue. We repeatedly bent a total of 35 strips of fresh and treated tissue to curvatures ranging from 0.2 to 2.2 mm-1. We compared the stiffness of the two materials between circumferential and radial bending, natural and reverse curvatures and constant or variable tensile stress (0.8-40 kPa). Our results showed a weak positive relationship between bending stiffness and applied tensile stress and a strong positive dependance of stiffness on tissue thickness (t). For the fresh tissue, the bending stiffness increased in proportion to t1.14 while for the glutaraldehyde treated tissue it increased with t2.18. Fourteen strips of fresh and treated tissue were also histologically processed, sectioned and examined with polarized light microscopy. Collagen fiber wavelengths and shear deformations were measured utilizing the tissue banding patterns produced by polarized light microscopy. The neutral axis of bending was found to lie very close to the outer surface of the tissue, sug...Continue Reading

References

Jan 1, 1979·Annual Review of Biophysics and Bioengineering·R I Jennrich, M L Ralston
Sep 1, 1988·The Annals of Thoracic Surgery·I VeselyT Song
Oct 1, 1987·Journal of Biomedical Engineering·E A Trowbridge, C E Crofts
Nov 1, 1986·Journal of Biomedical Materials Research·S L HilbertW M Swanson
Jan 1, 1986·Journal of Biomechanics·M S HamidP D Stein
Jan 1, 1985·Journal of Biomechanics·I Vesely, D R Boughner
Mar 14, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J DiamantR G Arridge
Jun 1, 1973·[Zasshi] [Journal]·D N Ross
Jan 1, 1984·The Annals of Thoracic Surgery·J L PomarC M Grondin
Jan 1, 1983·Journal of Biomechanics·A A SaurenJ D Janssen
Jan 1, 1982·Journal of Biomechanics·M Thubrikar, R T Eppink
Nov 1, 1982·Journal of Biomedical Materials Research·M J ThubrikarS P Nolan
Nov 1, 1980·The American Journal of Cardiology·V J FerransW C Roberts
Nov 1, 1980·Circulation Research·M ThubrikarS P Nolan
Sep 1, 1980·The Annals of Thoracic Surgery·M ThubrikarS P Nolan

❮ Previous
Next ❯

Citations

Aug 1, 1996·Journal of Biomedical Materials Research·P F GratzerJ M Lee
Jun 16, 2001·Journal of Biomedical Materials Research·J Lovekamp, N Vyavahare
Mar 19, 2011·Biomechanics and Modeling in Mechanobiology·Choon Hwai YapAjit P Yoganathan
Feb 26, 2011·Annals of Biomedical Engineering·Peter E HammerRobert D Howe
Oct 1, 1995·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·I Vesely
Jul 13, 2000·The Annals of Thoracic Surgery·K J GrandeK S Kunzelman
May 21, 1998·Journal of Biomechanics·I Vesely
Sep 26, 2006·Tissue Engineering·Yaling ShiIvan Vesely
Jan 18, 2007·Journal of Biomechanical Engineering·Mark A Nicosia
May 6, 2009·Annual Review of Biomedical Engineering·Michael S SacksJohn E Mayer
Apr 15, 2014·Cardiovascular Engineering and Technology·David A PrawelSusan P James
Dec 3, 2013·Journal of Biomechanics·Anwarul HasanAli Khademhosseini
Jun 5, 2001·The Annals of Thoracic Surgery·E A Talman, D R Boughner
Mar 1, 1992·Journal of Cardiac Surgery·I VeselyG Campbell
Dec 3, 2013·Biomechanics and Modeling in Mechanobiology·Rachel M Buchanan, Michael S Sacks
May 6, 2006·Tissue Engineering·Michael R Neidert, Robert T Tranquillo
Feb 22, 2012·Journal of Biomechanics·Peter E HammerRobert D Howe
Jan 2, 2009·Journal of Biomechanics·Gregory M WilliamsRobert L Sah
Oct 1, 1990·IEEE Transactions on Bio-medical Engineering·I VeselyG Campbell
Nov 1, 1991·IEEE Transactions on Bio-medical Engineering·I VeselyG Campbell
Mar 15, 2006·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Qiang QiuJames C Lacefield
May 1, 1992·The Annals of Thoracic Surgery·R W FraterE Wickham
Jun 9, 2001·IEEE Transactions on Bio-medical Engineering·K J Grande-AllenK S Kunzelman
Mar 17, 2015·Journal of Biomedical Materials Research. Part a·Christopher M HobsonWilliam R Wagner
Jan 29, 2013·Journal of Healthcare Engineering·Dan T SimionescuJun Liao
Apr 21, 2016·Biomechanics and Modeling in Mechanobiology·Milan TomaKaryn S Kunzelman
Oct 6, 2012·Acta Biomaterialia·Chad E EckertMichael S Sacks
Jan 1, 1992·Journal of Biomechanics·I Vesely, R Noseworthy
Apr 15, 2008·Ultrasound in Medicine & Biology·Zamir KhanJames C Lacefield
Dec 21, 2016·Cardiovascular Engineering and Technology·Sharan RamaswamyFrank Scholl
Jun 2, 2005·Circulation·Fraser W H SutherlandJohn E Mayer
Oct 15, 2005·Circulation Research·Ivan Vesely
Aug 28, 1999·Journal of Biomechanical Engineering·E O CarewI Vesely
Feb 7, 2007·Expert Review of Medical Devices·Michael S SacksPaul Schmidt
Dec 10, 2014·Annals of Biomedical Engineering·Arash KheradvarSuncica Canic
Aug 1, 2015·Annals of Biomedical Engineering·Arash KheradvarBoyce Griffith
Oct 5, 2016·Annals of Biomedical Engineering·Charles H BloodworthAjit P Yoganathan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.