PMID: 21260Sep 1, 1977

Analysis of the beta-receptor mediated effect on slow-contracting skeletal muscle in vitro

The Journal of Pharmacy and Pharmacology
B Waldeck

Abstract

Subtetanic contractions of the guinea-pig isolated soleus, a slow-contracting skeletal muscle, were evoked by transmural field-stimulation. Isoprenaline caused a dose-dependent depression of the contractions. This effect was inhibited by propranolol and H 35/25 (1-(p-tolyl-2-isopropylamino-1-propanol) but not by practolol. Similar results were obtained for terbutaline. Tazolol and H 80/62 (1-isopropylamino-3-(p-hydroxyphenoxy)-2-propanol (HCl), selective beta1-agonists, had no effect per se but inhibited the effect of terbutaline. Adrenaline, noradrenaline, and dopamine all caused a dose-dependent decrease in the force of the soleus contractions, their potencies being in that order. Tyramine did not appreciably affect the contractions nor did it inhibit the effect of terbutaline. Pretreatment with reserpine, if anything, increased the response to terbutaline. It is concluded, in conformity with previous in vivo studies, that the adrenergic receptor mediating the effect on the soleus muscle contractions is of the beta2-type. Indirect sympathomimetic effects do not contribute to the responses observed on the isolated soleus muscle.

References

Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks
Sep 15, 1969·Experientia·J BergmanK Wetterlin
Nov 15, 1972·Experientia·A P RoszkowskiJ H Fried
Feb 1, 1969·European Journal of Pharmacology·B Levy, B E Wilkenfeld

Citations

Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Holmberg, B Waldeck
Mar 1, 1990·Pharmacology & Toxicology·L H JohanssonE Rosengren
Jan 1, 1979·Acta Pharmacologica Et Toxicologica·B Waldeck
Jul 1, 1985·Clinical and Experimental Pharmacology & Physiology·B Waldeck, E Widmark
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·U Johansson, B Waldeck
Feb 1, 1980·Acta Pharmacologica Et Toxicologica·E Holmberg, B Waldeck
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·H MattssonE Carlsson
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·F A TibayanM A Matthay
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·A HedbergE Carlsson
Dec 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H MattssonT Olsson
Jun 1, 2000·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·T MoritaS Kondo

Related Concepts

Adrenergic beta-Antagonists
Intropin
Electric Stimulation Technique
Medihaler-Epi
Cavia porcellus
Novodrin
Inotropism
Norepinephrine, (+, -)-Isomer
Propanolamines
Norepinephrine Receptors

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