Abstract
Current cardiovascular randomized trials typically use composite outcomes. We hypothesized that the Bypass Angioplasty Revascularization Investigation (BARI) outcomes and conclusions would differ using a multistate model relative to the intervention for the composite outcome of death (D) and nonfatal Q-wave myocardial infarction (MI). We used a multistate model which uses transition paths to simultaneously assess multiple end points. Using the 10-year follow-up BARI data, we post hoc analyzed outcomes according to 3 transition paths: (1) from intervention to MI; (2) from intervention to death; and (3) from MI to death. Of 1,829 patients randomized to the intervention of percutaneous transluminal coronary angioplasty or coronary artery bypass grafting (CABG), 700 (38%) experienced the composite event D/MI which included 230 (13%) nonfatal MI and 470 (26%) death without antecedent nonfatal MI, whereas 79 of 230 (34%) experienced death after nonfatal MI. Outcomes of the 3 individual transition paths were analyzed by a multistate model. In contrast to standard survival analyses, after adjustment for baseline clinical covariates, outcomes after percutaneous transluminal coronary angioplasty or CABG were not significantly different f...Continue Reading
References
Oct 20, 1994·The New England Journal of Medicine·S B KingX Q Zhao
Jul 25, 1996·The New England Journal of Medicine·UNKNOWN Bypass Angioplasty Revascularization Investigation (BARI) Investigators
Jan 13, 1998·Journal of the American College of Cardiology·W S WeintraubS B King
Mar 1, 2000·Statistics in Medicine·P K AndersenT I Sorensen
Mar 29, 2000·Statistics in Medicine·S ChevretC Chastang
Apr 6, 2000·The New England Journal of Medicine·K M DetreB R Chaitman
Sep 28, 2000·The New England Journal of Medicine
Jan 12, 2001·Journal of the American College of Cardiology·A RodriguezW O'Neill
Jun 15, 2001·Statistics in Medicine·N KeidingM M Horowitz
Aug 16, 2005·Journal of the American College of Cardiology·Alfredo E RodriguezUNKNOWN ERACI II Investigators
Jul 19, 2006·Biometrical Journal. Biometrische Zeitschrift·Hein PutterCornelis J H van de Velde
Oct 13, 2006·Statistics in Medicine·H PutterR B Geskus
Apr 22, 2008·Statistics in Medicine·Marta FioccoHans C van Houwelingen
Jul 9, 2008·Circulation·Jean BoothUNKNOWN SoS Investigators
May 4, 2010·Statistics in Medicine·Baojiang ChenRichard J Cook
Mar 29, 2012·The New England Journal of Medicine·William S WeintraubFred H Edwards
Nov 6, 2012·The New England Journal of Medicine·Michael E FarkouhUNKNOWN FREEDOM Trial Investigators
Dec 7, 2013·Statistics in Medicine·A S C ConlonD J Sargent
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Subodh VermaJan O Friedrich
Jun 19, 2014·Blood·Quentin A HillRoger G Owen
Citations
May 30, 2016·Revista Española De Cardiología·Morteza HajihosseiniJavad Faradmal
Jun 18, 2016·Scientific Reports·Zhize YuanQiang Zhao
Nov 10, 2017·Statistical Methods in Medical Research·Hilary Aralis, Ron Brookmeyer
Apr 11, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·S Scott SuttonJames W Hardin
Apr 19, 2018·Inflammatory Bowel Diseases·Parakkal DeepakDavid H Bruining
Jul 31, 2021·Revista Española De Cardiología·Xavier Rossello, Maribel González-Del-Hoyo