PMID: 8954175Jan 1, 1996Paper

Analysis of the cellular origin of hepatocellular carcinoma by p53 genotype

Journal of Cancer Research and Clinical Oncology
B HeG Zhou

Abstract

The polymerase chain reaction and HaeIII enzymatic digestion were used to study the seventh exon of the p53 gene in 29 primary and recurrent hepatomas in paraffin-embedded samples from 11 patients. The mutation rate of the p53 gene and its genotypes in samples of primary and recurrent tumours and multiple nodules were investigated. The cellular origins of hepatocellular carcinoma were analysed by p53 genotype. p53 mutation rates were found to be 69.0% (20/29) in the primary and recurrent tumours, 58.8% (10/17) in tumours with a single nodule and 83.3% (10/12) in tumours with multiple nodules. The p53 genotypes were found to be different in 6 pairs of primary and recurrent tumours, and another 5 pairs had the same p53 genotypes. The samples with multiple nodules in the same patients had the same p53 genotypes. Seven recurrences were of multicentric origin and four were of unicentric origin. It is suggested that the recurrent lesions developed from both unicentric and multicentric origins.

References

Jul 1, 1991·Digestive Diseases and Sciences·R G SimonettiL Pagliaro
Aug 29, 1991·Nature·N K HaywardE Cooksley
Jan 1, 1991·Journal of Gastroenterology and Hepatology·X H LiangC H Schröder
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1991·Nature·A J LevineC A Finlay
Feb 1, 1989·Gastroenterology·P J ChenJ L Sung
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·H UnsalM Ozturk

❮ Previous
Next ❯

Citations

Mar 30, 2000·Journal of Surgical Oncology·M SakonM Monden
Dec 1, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masato SakonHiroaki Nagano
Nov 5, 2005·Biochemical and Biophysical Research Communications·Bin YangWen-Qin Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.