Analysis of the circular RNA transcriptome in endometrial cancer

Oncotarget
Bei Jun ChenMichael Janitz

Abstract

Circular RNAs (circRNAs) are a naturally occurring family of non-coding RNA that may regulate gene expression in mammals. circRNAs are more stable than messenger RNAs due to their resistance to RNA exonuclease. A growing body of evidence has shown that the expression of circRNAs is regulated during development in a tissue-specific manner. CircRNAs have been implicated in a number of cancers; however, their role in endometrial cancer (EC) is completely unknown. Here, we report the circular transcriptome specific for EC as determined by RNA sequencing. We found that the overall abundance of circRNAs is lower in EC than in normal endometrium. Further, there are numerous 'hotspot' genes from which circRNAs are transcribed that may account for alterations in circRNA expression between the normal and malignant endometrium. Most importantly, we have also identified circRNAs that are differentially expressed between malignant and normal endometrial tissue. The functional significance of these circRNAs in cancer remains to be determined, but they may serve as potential biomarkers for the diagnosis of EC or monitoring of EC progression.

References

Feb 1, 1983·Gynecologic Oncology·J V Bokhman
Apr 7, 2000·Carcinogenesis·E WeiderpassJ A Baron
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Sep 11, 2007·Urologic Oncology·Fedra GottardoRaffaele Baffa
Jan 19, 2010·Bioinformatics·Heng Li, Richard Durbin
Jun 21, 2011·Genome Research·Michael Schnall-LevinBonnie Berger
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
Sep 17, 2013·Molecular Cell·Yang ZhangLing-Ling Chen
Sep 17, 2013·PLoS Genetics·Julia SalzmanPatrick O Brown
Mar 13, 2014·PloS One·Peter L WangJulia Salzman
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
May 9, 2014·Nature Biotechnology·William R Jeck, Norman E Sharpless
Jul 30, 2014·Genome Biology·Junjie U GuoDavid P Bartel
Sep 11, 2014·Cancer Research·Frances L ByrneKyle L Hoehn
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Sep 23, 2014·Molecular Cell·Reut Ashwal-FlussSebastian Kadener
Sep 23, 2014·Cell·Xiao-Ou ZhangLi Yang
Sep 12, 2015·Lancet·Philippe MoriceEmile Darai
Jun 19, 2016·Genome Biology·Yujiao DangJie Qiao
Oct 25, 2016·Journal of Neurochemistry·Bei Jun ChenMichael Janitz
Oct 19, 2016·International Journal of Molecular Sciences·Hitoshi SuzukiToshifumi Tsukahara
Jan 29, 2017·Histopathology·Benjamin GoeppertMarcus Renner
Mar 25, 2017·International Journal of Oncology·Ya-Sian ChangJan-Gowth Chang
Oct 21, 2017·Gynecologic Oncology·Bei Jun ChenMichael Janitz

❮ Previous
Next ❯

Citations

Jul 25, 2018·International Journal of Molecular Sciences·Alessandro La FerlitaCinzia Di Pietro
Sep 11, 2019·International Journal of Molecular Sciences·Karol CzubakMarzena Wojciechowska
Mar 27, 2020·Frontiers in Cell and Developmental Biology·Anh M TranGeorge A Calin
Jun 5, 2020·Scientific Reports·Zhi-Ye ZhangShuang-Shuang Guo
Oct 6, 2020·Nucleic Acid Therapeutics·Kenji HagiwaraFumikazu Shinohara
Nov 11, 2020·Journal of Cellular and Molecular Medicine·Yun LiuYixuan Cai
May 3, 2019·Journal of Animal Science and Biotechnology·Yuxuan SongBinyun Cao
Dec 9, 2020·Critical Reviews in Oncology/hematology·Zahra Sadat RazaviHamed Mirzaei
Feb 6, 2021·Journal of Cellular and Molecular Medicine·Arunagiri Kuha Deva Magendhra RaoSamson Mani
Jan 1, 2020·Current Gene Therapy·Luis María Vaschetto
Dec 29, 2020·Technology in Cancer Research & Treatment·Bo WuRuizhen Huang
Feb 27, 2021·Cancer Management and Research·Jialu GuoJianfeng Zheng
May 27, 2021·Clinical Epigenetics·Alejandra Monserrat Retis-ResendizEdgar Ricardo Vázquez-Martínez
Sep 15, 2020·Neuroscience·Ashton Curry-HydeMichael Janitz
Sep 23, 2021·Journal of Cellular and Molecular Medicine·Sisi GuanWenjuan Zhang
Dec 17, 2021·Frontiers in Cell and Developmental Biology·Shuang YuanLihua Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-Seq

Software Mentioned

edgeR
MEM
Trimmomatic
BWA
R package

Related Concepts

Related Feeds

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.