Analysis of the complete genome of subgroup A' hepatitis B virus isolates from South Africa

The Journal of General Virology
Anna KramvisMichael C Kew

Abstract

A phylogenetic analysis is presented of six complete and seven pre-S1/S2/S gene sequences of hepatitis B virus (HBV) isolates from South Africa. Five of the full-length sequences and all of the pre-S2/S sequences have been previously reported. Four of the six complete genomes and three of the five incomplete sequences clustered with subgroup A', a unique segment of genotype A of HBV previously identified in 60% of South African isolates using analysis of the pre-S2/S region alone. This separation was also evident when the polymerase open reading frame was analysed, but not on analysis of either the X or pre-core/core genes. Amino acids were identified in the pre-S1 and polymerase regions specific to subgroup A'. In common with genotype D, 10 of 11 genotype A South African isolates had an 11 amino acid deletion in the amino end of the pre-S1 region. This deletion is also found in hepadnaviruses from non-human primates.

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Citations

Jan 10, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sandrine François-SouquièreMirdad Kazanji
Feb 24, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Souleymane BrahPhilippe Colson
Jun 26, 2015·Journal of Gastroenterology and Hepatology·Kiyoaki ItoUNKNOWN Japanese AHB CHB Study Group
Feb 16, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mahmoud Reza PourkarimMarc Van Ranst
Oct 28, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mahmoud Reza PourkarimMarc Van Ranst
Aug 18, 2009·Cancer Letters·Flor Helene PujolIsabelle Chemin
Oct 17, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Judith M HübschenClaude P Muller
Aug 11, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Claudine BekondiVéronique Venard
May 29, 2009·Reviews in Medical Virology·Iris E AndernachClaude P Muller
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Masaya SugiyamaMasashi Mizokami
Dec 25, 2010·Journal of Medical Virology·Zandiswa GulubeAnna Kramvis
Jul 22, 2010·Journal of Medical Virology·Tatiana DupinayHeléne Norder
Mar 9, 2005·Vaccine·Anna KramvisGuido François
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Jul 21, 2005·Journal of Medical Virology·Hiroshi YotsuyanagiUNKNOWN Japanese Acute Hepatitis B Group
Jul 23, 2009·Journal of Medical Virology·Raquel VianaMichael C Kew

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