PMID: 6409946Aug 1, 1983Paper

Analysis of the complexity of the multimeric structure of factor VIII related antigen/von Willebrand protein using a modified electrophoretic technique

Journal of Clinical Pathology
M S Enayat, F G Hill

Abstract

A method for multimeric analysis of factor VIII related antigen/von Willebrand protein is described. By modifying an existing method the technique has been simplified and optimised so that the different molecular forms of factor VIII related antigen and their triplet structure can be visualised. Clear differences can be seen between patterns in normals and type IIA von Willebrand's disease variants in that the latter lack high and intermediate multimers and also have a different configuration to the triplet pattern in the lower molecular weight multimers. Differences in triplet pattern can also be seen in different type IIA patients. The advantages and further application of this method for investigating the molecular defect in von Willebrand's disease are discussed.

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Citations

Jan 1, 1984·Molecular Aspects of Medicine·P Knox
May 2, 1987·Lancet·R G DaltonF E Preston
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H R GralnickM E Rick
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Jul 13, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·P K GuptaR Saxena
Oct 24, 2018·Research and Practice in Thrombosis and Haemostasis·Annette E BowyerMichael Makris
Dec 6, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Joerg KellermairClemens Steinwender
Jan 1, 1984·Clinical and Laboratory Haematology·E G Tuddenham
Apr 15, 1988·Thrombosis Research·P HarrisonG F Savidge

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