PMID: 11927837Apr 3, 2002Paper

Analysis of the CYP2C19 polymorphism in a North-eastern Thai population

Pharmacogenetics
Wichittra TassaneeyakulDhanu Gaysornsiri

Abstract

CYP2C19 is a polymorphically expressed cytochrome P450 responsible for the metabolism of several clinically used drugs, including some barbiturates, diazepam, proguanil, propranolol and several proton pump inhibitors. Genetic polymorphism of this enzyme shows marked interracial differences, with the poor metabolizer (PM) phenotype representing 2-5% of Caucasian and 11-23% of Oriental populations. In the present study, CYP2C19 phenotype and genotype were investigated in 107 North-eastern Thai subjects using the omeprazole hydroxylation index (HI) and polymerase chain reaction-restriction fragment length polymorphism technique, respectively. It was found that the distribution of HI in these subjects was bimodal. Seven subjects [6.54%, 95% confidence (CI) 1.86-11.22%] were identified as PM, with an HI > 7. Analysis of CYP2C19 genotypes in these 107 Thai subjects revealed that the allele frequencies for CYP2C19*1, CYP2C19*2 and CYP2C19*3 were 0.71 (95% CI 0.65-0.77), 0.27 (95% CI 0.21-0.33) and 0.02 (95% CI 0.01-0.05), respectively. The PM phenotype and the frequencies of CYP2C19 defective alleles in Thais, particularly CYP2C19*3, were lower than those observed in other Oriental populations. It is noteworthy that there was a case o...Continue Reading

References

Jan 1, 1990·European Journal of Clinical Pharmacology·G AlvánU Gundert-Remy
Jul 1, 1990·Therapeutic Drug Monitoring·T AnderssonL Bertilsson
Jan 1, 1989·Pharmacology & Therapeutics·G R WilkinsonR A Branch
Jan 1, 1989·Clinical Pharmacology and Therapeutics·S A WardR A Branch
Oct 1, 1985·Clinical Pharmacology and Therapeutics·A Küpfer, R A Branch
Jan 1, 1984·European Journal of Clinical Pharmacology·A Küpfer, R Preisig
Dec 1, 1984·Clinical Pharmacology and Therapeutics·P J WedlundR A Branch
Oct 1, 1995·Clinical Pharmacology and Therapeutics·S M de MoraisH H Zhou
Jun 1, 1995·Clinical Pharmacology and Therapeutics·J D BalianD A Flockhart
Jan 1, 1994·British Journal of Clinical Pharmacology·M D EdsteinH K Webster
Aug 1, 1993·British Journal of Clinical Pharmacology·K BrøsenH Flachs
Aug 1, 1996·Clinical Pharmacology and Therapeutics·J S MarinacD A Flockhart
Dec 1, 1995·Pharmacogenetics·S H Sindrup, K Brøsen
Dec 1, 1996·Clinical Pharmacology and Therapeutics·T KubotaT Ishizaki
May 26, 1999·Clinical Pharmacology and Therapeutics·T FurutaT Ishizaki
Feb 15, 2000·British Journal of Clinical Pharmacology·W TassaneeyakulY Yamazoe
Nov 4, 2000·Nature Genetics·P A UnderhillP J Oefner

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Citations

Jan 22, 2005·European Journal of Clinical Pharmacology·J RosemaryR Krishnamoorthy
Nov 4, 2008·European Journal of Clinical Pharmacology·M I VeigaJ P Gil
Apr 2, 2010·Rheumatology International·Pintip NgamjanyapornSuchela Janwityanujit
Apr 6, 2005·Trends in Pharmacological Sciences·Guilherme Suarez-Kurtz
Feb 16, 2007·Pharmacogenetics and Genomics·Kaori NakamotoXiao-Bo Zhong
Dec 20, 2005·Journal of Gastroenterology and Hepatology·P W Y LimB C Y Wong
Aug 26, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Suksiri SiriswangvatDuangchit Panomvana
May 14, 2010·Future Cardiology·Richard L SeipGualberto Ruaño
Aug 2, 2007·Therapeutic Drug Monitoring·Sang Seop LeeJae-Gook Shin
Apr 7, 2004·Journal of Pharmaceutical Sciences·Konomu SaitoShoichi Fujita
Jun 23, 2004·British Journal of Clinical Pharmacology·Somrudee SrimartpiromWichittra Tassaneeyakul
Oct 11, 2003·Journal of Clinical Pharmacology·Héctor M GonzalezCarlos Hoyo-Vadillo
Aug 16, 2003·British Journal of Clinical Pharmacology·C AdithanR Krishnamoorthy
Mar 13, 2003·British Journal of Clinical Pharmacology·Veerapol KukongviriyapanBenjamart Warasiha
Apr 5, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Wiparat ManuyakornSuwat Benjaponpitak
Dec 17, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Maryam PayanReza Tahvilian
Sep 2, 2006·Drug Metabolism and Pharmacokinetics·Wichittra TassaneeyakulWongwiwat Tassaneeyakul
Jun 9, 2006·Medicina clínica·Hortensia Alonso-NavarroJosé A García-Agúndez
Oct 9, 2021·Journal of Gastroenterology and Hepatology·Chalermrat Bunchorntavakul, Arunluk Buranathawornsom

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