Abstract
CYP2C19 is a polymorphically expressed cytochrome P450 responsible for the metabolism of several clinically used drugs, including some barbiturates, diazepam, proguanil, propranolol and several proton pump inhibitors. Genetic polymorphism of this enzyme shows marked interracial differences, with the poor metabolizer (PM) phenotype representing 2-5% of Caucasian and 11-23% of Oriental populations. In the present study, CYP2C19 phenotype and genotype were investigated in 107 North-eastern Thai subjects using the omeprazole hydroxylation index (HI) and polymerase chain reaction-restriction fragment length polymorphism technique, respectively. It was found that the distribution of HI in these subjects was bimodal. Seven subjects [6.54%, 95% confidence (CI) 1.86-11.22%] were identified as PM, with an HI > 7. Analysis of CYP2C19 genotypes in these 107 Thai subjects revealed that the allele frequencies for CYP2C19*1, CYP2C19*2 and CYP2C19*3 were 0.71 (95% CI 0.65-0.77), 0.27 (95% CI 0.21-0.33) and 0.02 (95% CI 0.01-0.05), respectively. The PM phenotype and the frequencies of CYP2C19 defective alleles in Thais, particularly CYP2C19*3, were lower than those observed in other Oriental populations. It is noteworthy that there was a case o...Continue Reading
References
Jun 1, 1991·British Journal of Clinical Pharmacology·S A WardA M Breckenridge
Jan 1, 1990·European Journal of Clinical Pharmacology·G AlvánU Gundert-Remy
Jul 1, 1990·Therapeutic Drug Monitoring·T AnderssonL Bertilsson
Apr 1, 1989·Clinical Pharmacology and Therapeutics·L BertilssonT Villén
Jan 1, 1989·Pharmacology & Therapeutics·G R WilkinsonR A Branch
Jan 1, 1989·Clinical Pharmacology and Therapeutics·S A WardR A Branch
Oct 1, 1985·Clinical Pharmacology and Therapeutics·A Küpfer, R A Branch
Jan 1, 1984·European Journal of Clinical Pharmacology·A Küpfer, R Preisig
Dec 1, 1984·Clinical Pharmacology and Therapeutics·P J WedlundR A Branch
Sep 1, 1995·Clinical Pharmacology and Therapeutics·C PartovianC Funck-Brentano
Oct 1, 1995·Clinical Pharmacology and Therapeutics·S M de MoraisH H Zhou
May 1, 1995·British Journal of Clinical Pharmacology·M ChangL Bertilsson
Jun 1, 1995·Clinical Pharmacology and Therapeutics·J D BalianD A Flockhart
May 1, 1994·British Journal of Clinical Pharmacology·D J BirkettM E Veronese
Aug 1, 1994·Clinical Pharmacology and Therapeutics·R SetiabudyT Ishizaki
Jan 1, 1994·British Journal of Clinical Pharmacology·M D EdsteinH K Webster
Aug 1, 1993·British Journal of Clinical Pharmacology·K BrøsenH Flachs
Oct 1, 1995·Pharmacogenetics·K BrøsenJ A Goldstein
Dec 1, 1995·Pharmacogenetics·M ChangL Bertilsson
Jan 1, 1996·Methods in Enzymology·J A Goldstein, J Blaisdell
Aug 1, 1996·Clinical Pharmacology and Therapeutics·J S MarinacD A Flockhart
Dec 1, 1995·Pharmacogenetics·S H Sindrup, K Brøsen
Dec 1, 1996·Clinical Pharmacology and Therapeutics·T KubotaT Ishizaki
Dec 1, 1996·Pharmacogenetics·H K RohL Bertilsson
Mar 29, 1997·Lancet·A KanekoT Kobayakawa
Feb 1, 1997·Pharmacogenetics·J A GoldsteinD A Evans
Nov 3, 1998·Clinical Pharmacology and Therapeutics·K HerrlinL L Gustafsson
Dec 29, 1998·Annals of Internal Medicine·T FurutaE Kaneko
Feb 18, 1999·Pharmacogenetics·G C IbeanuJ A Goldstein
May 26, 1999·Clinical Pharmacology and Therapeutics·T FurutaT Ishizaki
Feb 15, 2000·British Journal of Clinical Pharmacology·W TassaneeyakulY Yamazoe
Sep 8, 2000·Clinical Pharmacology and Therapeutics·K HerrlinL L Gustafsson
Nov 4, 2000·Nature Genetics·P A UnderhillP J Oefner
Citations
Jan 22, 2005·European Journal of Clinical Pharmacology·J RosemaryR Krishnamoorthy
Nov 4, 2008·European Journal of Clinical Pharmacology·M I VeigaJ P Gil
Apr 2, 2010·Rheumatology International·Pintip NgamjanyapornSuchela Janwityanujit
Apr 6, 2005·Trends in Pharmacological Sciences·Guilherme Suarez-Kurtz
Feb 16, 2007·Pharmacogenetics and Genomics·Kaori NakamotoXiao-Bo Zhong
Dec 20, 2005·Journal of Gastroenterology and Hepatology·P W Y LimB C Y Wong
Mar 13, 2003·Gut·I L P Beales
Aug 26, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Suksiri SiriswangvatDuangchit Panomvana
Sep 1, 2004·Pharmacogenomics·Alan Morrison, Richard Levy
Jun 4, 2008·Pharmacogenomics·Lingling ChenQinghe Xing
Nov 15, 2012·Pharmacogenomics·Li-Ming HuJian-Ping Cai
May 14, 2010·Future Cardiology·Richard L SeipGualberto Ruaño
Aug 2, 2007·Therapeutic Drug Monitoring·Sang Seop LeeJae-Gook Shin
Apr 7, 2004·Journal of Pharmaceutical Sciences·Konomu SaitoShoichi Fujita
Jun 23, 2004·British Journal of Clinical Pharmacology·Somrudee SrimartpiromWichittra Tassaneeyakul
Oct 11, 2003·Journal of Clinical Pharmacology·Héctor M GonzalezCarlos Hoyo-Vadillo
Aug 16, 2003·British Journal of Clinical Pharmacology·C AdithanR Krishnamoorthy
Mar 13, 2003·British Journal of Clinical Pharmacology·Veerapol KukongviriyapanBenjamart Warasiha
Apr 5, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Wiparat ManuyakornSuwat Benjaponpitak
Sep 14, 2010·Journal of Clinical Pharmacy and Therapeutics·V W Y LeeF K L Chan
Jun 13, 2014·Proteomics·Xidong LiuJingkai Gu
Dec 17, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Maryam PayanReza Tahvilian
Sep 2, 2006·Drug Metabolism and Pharmacokinetics·Wichittra TassaneeyakulWongwiwat Tassaneeyakul
Oct 28, 2015·The Pharmacogenomics Journal·I Fricke-GalindoA LLerena
Oct 29, 2019·Coronary Artery Disease·Sornsith JirungdaWit Leuangwatthananon
Jun 9, 2006·Medicina clínica·Hortensia Alonso-NavarroJosé A García-Agúndez
Oct 9, 2021·Journal of Gastroenterology and Hepatology·Chalermrat Bunchorntavakul, Arunluk Buranathawornsom