Analysis of the Different Metabolic Phenotypes of Metalaxyl Enantiomers in Adolescent Rat by Using 1H NMR Based Urinary Metabolomics.
Abstract
Over 30% of commercial pesticides are racemic mixtures. Nowadays, the environmental safety of chiral pesticides has received more and more attention. Metalaxyl is a broad-spectrum fungicide with systemic function, which has a chiral carbon. Although its fungicidal activity almost entirely originates from the R-enantiomer, the enantioselective toxicity of metalaxyl in animals and human beings are not yet clear. In this study, the urinary metabolomics approach was applied to analyze the changes in metabolic phenotypes in adolescent rats by using nuclear magnetic resonance (NMR). In the urinary metabolomics results, the metabolic profiles of the different enantiomers were distinguishable, and the characteristic metabolites were different. Both in the exposure of R/S-enantiomers, the disturbed metabolic pathways in common were butanoate metabolism, valine, leucine and isoleucine biosynthesis, alanine, aspartate and glutamate metabolism, and glutamine and glutamate metabolism. These pathways were closely involved in gut microbiota. In addition to the disturbed metabolic pathways common to both, three metabolic pathways were abnormal in the exposure of S-metalaxyl, including aminoacyl-tRNA biosynthesis, arginine biosynthesis, and cit...Continue Reading
References
Exposure to the fungicide propamocarb causes gut microbiota dysbiosis and metabolic disorder in mice
Related Concepts
Related Feeds
Antifungals
An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.