Analysis of the Dreissena polymorpha gill proteome following exposure to dioxin-like PCBs: mechanism of action and the role of gender

Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
C Riva, A Binelli

Abstract

PCBs are a persistent environmental problem due to their high stability and lipophilicity. The non-ortho- and the mono-ortho-substituted PCBs (dioxin-like-PCBs) share a common and well-described toxicity mechanism in vertebrates, initially involving binding to cytosolic AhRs. Invertebrate AhRs, however, show a lack of dioxin binding, and little information is available regarding the mechanism of toxicity of dl-PCBs in invertebrates. In this study, a proteomic approach was applied to analyse the variations in the pattern of the gill proteome of the freshwater mussel Dreissena polymorpha. Mussels were exposed to a mixture of dl-PCBs, and to perform a more in-depth evaluation, we chose to investigate the role of gender in the proteome response by analysing male and female mussels separately. The results revealed significant modulation of the gill tissue proteome: glycolysis and Ca(2+) homeostasis appear to be the main pathways targeted by dl-PCBs. In light of the differences between the male and female gill proteome profiles following exposure to dl-PCBs, further in-depth investigations of the role of gender in the protein expression profiles of a selected biological model are required.

References

Dec 1, 1991·Toxicology and Applied Pharmacology·M Göttlicher, F J Wiebel
Jun 26, 1981·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C C Blake, D W Rice
Jan 1, 1993·Free Radical Research Communications·J ZdolsekU Brunk
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A Powell-CoffmanW B Wood
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·B CanbackC G Kurland
Sep 6, 2002·Chemico-biological Interactions·Mark E Hahn
Nov 1, 2002·Marine Environmental Research·Amagoia Gómez-MendikuteMiren P Cajaraville
Dec 31, 2002·Toxicology·Alvaro PugaErik S Knudsen
Feb 8, 2003·Biochimica Et Biophysica Acta·Junsei Mimura, Yoshiaki Fujii-Kuriyama
Jul 31, 2003·Biological Chemistry·Shiqing Yan, Bonnie F Sloane
Nov 24, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·L D Kraemer, P M Schulte
Mar 12, 2005·Experimental & Molecular Medicine·Sun-Young Kim, Jae-Ho Yang
Jun 1, 2005·Electrophoresis·Wolfgang SchlagsBodo Lachmann
Sep 20, 2005·Biochemical and Biophysical Research Communications·Silvia Franzellitti, Elena Fabbri
Feb 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·C E ChwieralskiF Bühling
Nov 14, 2006·Environmental Research·Patricia McClellan-GreenEva Oberdörster
Dec 1, 2006·Apoptosis : an International Journal on Programmed Cell Death·Nagathihalli S NagarajWolfgang Zacharias
Feb 1, 2007·The Journal of Clinical Endocrinology and Metabolism·Faidon MagkosBettina Mittendorfer
Sep 1, 2009·Aquatic Toxicology·Suze ChoraMaria João Bebianno
Dec 3, 2009·Proteomics·Marco F L LemosAna C Esteves

❮ Previous
Next ❯

Citations

Oct 28, 2014·Environmental Science & Technology·Judith TrappOlivier Geffard
Aug 11, 2015·Ecotoxicology and Environmental Safety·E GismondiJ P Thomé
Oct 2, 2015·Environmental Science and Pollution Research International·M J BebiannoF Geret

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis